Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Cpn - Calphotin

Drosophila melanogaster

Synonyms: 77H5, Ag 72H5, Ag72H5, CG4795, Dmel\CG4795, ...

Yang, Y. et al., Martin, J.H. et al., Ballinger, D.G. et al.

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High impact information on Cpn

Monoclonal antibody 23E9 identifies a calcium-binding protein, calphotin, in photoreceptor cells of the Drosophila melanogaster compound eyes and ocelli [1].
The calphotin protein binds calcium and contains a long C-terminal leucine zipper [2].
Transformation rescue of these phenotypes in transgenic flies bearing calphotin genomic DNA indicates that both classes of mutations are in the calphotin gene [3].
Calphotin is a very hydrophobic and proline-rich protein which lacks obvious transmembrane domains [3].
Mutations in calphotin, the gene encoding a Drosophila photoreceptor cell-specific calcium-binding protein, reveal roles in cellular morphogenesis and survival [3].

Biological context of Cpn

Analysis of these mutations suggest that Calphotin plays important roles in both rhabdomere development and in photoreceptor cell survival [3].

Anatomical context of Cpn

Calphotin: a Drosophila photoreceptor cell calcium-binding protein [1].

References

Calphotin: a Drosophila photoreceptor cell calcium-binding protein. Martin, J.H., Benzer, S., Rudnicka, M., Miller, C.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
A Drosophila photoreceptor cell-specific protein, calphotin, binds calcium and contains a leucine zipper. Ballinger, D.G., Xue, N., Harshman, K.D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
Mutations in calphotin, the gene encoding a Drosophila photoreceptor cell-specific calcium-binding protein, reveal roles in cellular morphogenesis and survival. Yang, Y., Ballinger, D. Genetics (1994) [Pubmed]

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