Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Rbp4 - RNA-binding protein 4

Drosophila melanogaster

Synonyms: CG9654, Dmel\CG9654, RRM4, TSR, Tsr, ...

Haynes, S.R. et al.

Haynes, Cooper, Pype, Stolow,

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High impact information on Rbp4

We have characterized the Testis-specific RRM protein gene (Tsr), which plays an important role in spermatogenesis in Drosophila melanogaster [1].
TSR protein was located in the cytoplasm of spermatocytes and young spermatids but was absent from mature sperm [1].
Lack of TSR resulted in the premature expression of a few proteins prior to meiosis; this was abolished by a transgenic copy of Tsr [1].

Anatomical context of Rbp4

These data demonstrate that TSR negatively regulated the expression of some testis proteins and, in combination with its expression pattern and subcellular localization, suggest that TSR regulates the stability or translatability of some mRNAs during spermatogenesis [1].

References

Involvement of a tissue-specific RNA recognition motif protein in Drosophila spermatogenesis. Haynes, S.R., Cooper, M.T., Pype, S., Stolow, D.T. Mol. Cell. Biol. (1997) [Pubmed]

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