Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Gyc88E - Guanylyl cyclase at 88E

Drosophila melanogaster

Synonyms: CG4154, Dmel\CG4154, GYC, Gyc-88E, Soluble guanylate cyclase 88E

Langlais, K.K. et al., Morton, D.B. et al., Morton, D.B. et al., Vermehren, A. et al.

Morton, Langlais, Stewart, Vermehren, Morton,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Gyc88E

Drosophila contains three genes that code for atypical soluble guanylyl cyclases: Gyc-88E, Gyc-89Da, and Gyc-89Db [1].
Preliminary data showed that transient expression of Gyc-88E in heterologous cells generated enzyme activity in the absence of additional subunits that was slightly stimulated by the NO donor sodium nitroprusside (SNP) but not the NO donor DEA-NONOate or the NO-independent activator YC-1 [2].
Here, we describe the localization of Gyc-88E and Gyc-89Db and show that they are expressed in the embryonic and larval central nervous systems and are colocalized in several peripheral neurons that innervate trachea, basiconical sensilla and the sensory cones in the posterior segments of the embryo [2].
Both Gyc-88E/89Da and Gyc-88E/89Db were expressed in neurons in both the peripheral and central nervous system [3].

Anatomical context of Gyc88E

Gyc-88E and Gyc-89Db are co-expressed in a subset of sensory neurons where they would be ideally situated to act as oxygen sensors [1].

Regulatory relationships of Gyc88E

Gyc-89Db was inactive when expressed alone but when co-expressed with Gyc-88E enhanced the basal and SNP-stimulated activity of Gyc-88E, suggesting that they may form heterodimers in vivo [2].
Gyc-89Da only forms an active guanylyl cyclase when co-expressed with Gyc-88E [3].

Other interactions of Gyc88E

By contrast, the Drosophila melanogaster atypical sGC subunits, Gyc-88E, Gyc-89Da and Gyc-89Db, are only slightly sensitive to NO, but are potently activated under hypoxic conditions [4].

References

Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors. Morton, D.B. J. Biol. Chem. (2004) [Pubmed]
Preliminary characterization of two atypical soluble guanylyl cyclases in the central and peripheral nervous system of Drosophila melanogaster. Langlais, K.K., Stewart, J.A., Morton, D.B. J. Exp. Biol. (2004) [Pubmed]
Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster. Morton, D.B., Langlais, K.K., Stewart, J.A., Vermehren, A. J. Insect Sci. (2005) [Pubmed]
Oxygen-sensitive guanylyl cyclases in insects and their potential roles in oxygen detection and in feeding behaviors. Vermehren, A., Langlais, K.K., Morton, D.B. J. Insect Physiol. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP001985	Anopheles gambiae str. PEST
gcy-31	Caenorhabditis elegans

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.