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Gene Review

Dad  -  Daughters against dpp

Drosophila melanogaster

Synonyms: 1883, CG5201, DAD, Dad1, Dmel\CG5201, ...
 
 
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High impact information on Dad

  • We have now isolated a gene, Daughters against dpp (Dad), whose transcription is induced by Dpp [1].
  • Expression of Dad together with either Mad or the activated receptor rescues phenotypic defects induced by each protein alone [1].
  • In contrast to the above model, we find that an enhancer trap inserted near the Dpp target gene, Daughters against Dpp (Dad), is expressed in additional somatic cells within the germarium, suggesting that Dpp protein may be distributed throughout the anterior germarium [2].
  • Conversely, autonomously inhibiting Dpp signaling using a pathway specific inhibitor, Dad, or a mutation in tkv, slowed wing cell growth and division, also in a coordinate fashion [3].
  • Our observations also suggest new roles for the dSmads, Med and Dad, in dActivin signaling and potential interactions between these family members [4].
 

Anatomical context of Dad

  • However, Dad-lacZ expression within the germline is present only in GSCs and to a lower level in CBs, suggesting there are mechanisms that actively restrict Dpp signaling in germ cells [2].
 

Other interactions of Dad

  • Tkv induces homo-oligomerization of Mad, and Dad inhibits this step [5].

References

  1. Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Tsuneizumi, K., Nakayama, T., Kamoshida, Y., Kornberg, T.B., Christian, J.L., Tabata, T. Nature (1997) [Pubmed]
  2. Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling. Casanueva, M.O., Ferguson, E.L. Development (2004) [Pubmed]
  3. A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing. Martín-Castellanos, C., Edgar, B.A. Development (2002) [Pubmed]
  4. Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Marquez, R.M., Singer, M.A., Takaesu, N.T., Waldrip, W.R., Kraytsberg, Y., Newfeld, S.J. Genetics (2001) [Pubmed]
  5. Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp. Inoue, H., Imamura, T., Ishidou, Y., Takase, M., Udagawa, Y., Oka, Y., Tsuneizumi, K., Tabata, T., Miyazono, K., Kawabata, M. Mol. Biol. Cell (1998) [Pubmed]
 
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