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Gene Review

tkv  -  thickveins

Drosophila melanogaster

Synonyms: Atkv, Atr25D, Brk25D, Brk25D1, Brk25D2, ...
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High impact information on tkv

  • Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning [1].
  • We propose that spatial regulation of the SAX pathway modulates TKV signaling to create positional information over the embryonic ectoderm [1].
  • Ubiquitous expression of a tkv transgene rescues both tkv and sax loss-of-function mutations [2].
  • Analysis of clones mutant for the Dpp receptors encoded by punt or thickveins (tkv) reveals that repression of wg expression is one critical function of Dpp signalling in leg and wing discs [3].
  • At this stage in development, thickveins, a dpp receptor, is expressed in the mesoderm, and this suggests that ectodermal dpp might not only be required for development of dorsal ectoderm, but could also act inductively to mediate pattern formation in the underlying mesoderm [4].

Biological context of tkv


Anatomical context of tkv


Physical interactions of tkv

  • Brk25D binds dpp protein and bone morphogenetic protein 2 with high affinity [11].

Regulatory relationships of tkv

  • smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye [12].
  • We present evidence that Dpp signaling negatively regulates tkv expression and that the level of receptor influences the effective range of the Dpp gradient [13].

Other interactions of tkv

  • mtv shapes the activity gradient of the Dpp morphogen through regulation of thickveins [14].
  • During larval development, the expression of spalt, a dpp target, was abolished in mutant wing discs, while it was restored by a constitutively activated form of Tkv (Tkv(Q253D)) [15].
  • In this report, we demonstrate that mtv integrates the activities of En and Hh that shape tkv expression pattern [14].
  • We suggest that regulation of tkv by HH is a key part of the mechanism that controls the level and distribution of DPP [16].
  • The type I receptor Thick veins (Tkv) and the R-Smad transcription factor Mothers-against-dpp (Mad) are localized postsynaptically in the muscle [17].

Analytical, diagnostic and therapeutic context of tkv

  • CONCLUSIONS: Our genomic-wide microarray analysis has revealed common targets for the tkv and babo pathways and provided new insights into downstream effectors of two distinct TGFbeta like pathways [18].


  1. Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning. Neul, J.L., Ferguson, E.L. Cell (1998) [Pubmed]
  2. Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Brummel, T.J., Twombly, V., Marqués, G., Wrana, J.L., Newfeld, S.J., Attisano, L., Massagué, J., O'Connor, M.B., Gelbart, W.M. Cell (1994) [Pubmed]
  3. Decapentaplegic restricts the domain of wingless during Drosophila limb patterning. Penton, A., Hoffmann, F.M. Nature (1996) [Pubmed]
  4. dpp induces mesodermal gene expression in Drosophila. Staehling-Hampton, K., Hoffmann, F.M., Baylies, M.K., Rushton, E., Bate, M. Nature (1994) [Pubmed]
  5. A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A. Chen, Y., Riese, M.J., Killinger, M.A., Hoffmann, F.M. Development (1998) [Pubmed]
  6. Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. Ralston, A., Blair, S.S. Dev. Biol. (2005) [Pubmed]
  7. Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family. Letsou, A., Arora, K., Wrana, J.L., Simin, K., Twombly, V., Jamal, J., Staehling-Hampton, K., Hoffmann, F.M., Gelbart, W.M., Massagué, J. Cell (1995) [Pubmed]
  8. Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis. Affolter, M., Nellen, D., Nussbaumer, U., Basler, K. Development (1994) [Pubmed]
  9. Oogenic function of the myogenic factor D-MEF2: negative regulation of the decapentaplegic receptor gene thick veins. Mantrova, E.Y., Schulz, R.A., Hsu, T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  10. Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function. Bradley, P.L., Myat, M.M., Comeaux, C.A., Andrew, D.J. Dev. Biol. (2003) [Pubmed]
  11. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Penton, A., Chen, Y., Staehling-Hampton, K., Wrana, J.L., Attisano, L., Szidonya, J., Cassill, J.A., Massagué, J., Hoffmann, F.M. Cell (1994) [Pubmed]
  12. smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye. Vrailas, A.D., Marenda, D.R., Cook, S.E., Powers, M.A., Lorenzen, J.A., Perkins, L.A., Moses, K. Development (2006) [Pubmed]
  13. Dpp receptor levels contribute to shaping the Dpp morphogen gradient in the Drosophila wing imaginal disc. Lecuit, T., Cohen, S.M. Development (1998) [Pubmed]
  14. mtv shapes the activity gradient of the Dpp morphogen through regulation of thickveins. Funakoshi, Y., Minami, M., Tabata, T. Development (2001) [Pubmed]
  15. The Drosophila tumor suppressor gene lethal(2)giant larvae is required for the emission of the Decapentaplegic signal. Arquier, N., Perrin, L., Manfruelli, P., Sémériva, M. Development (2001) [Pubmed]
  16. Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. Tanimoto, H., Itoh, S., ten Dijke, P., Tabata, T. Mol. Cell (2000) [Pubmed]
  17. Postsynaptic mad signaling at the Drosophila neuromuscular junction. Dudu, V., Bittig, T., Entchev, E., Kicheva, A., Jülicher, F., González-Gaitán, M. Curr. Biol. (2006) [Pubmed]
  18. Genome-wide microarray analysis of TGFbeta signaling in the Drosophila brain. Yang, M., Nelson, D., Funakoshi, Y., Padgett, R.W. BMC Dev. Biol. (2004) [Pubmed]
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