Gene Review:
SMOX - spermine oxidase
Gallus gallus
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Disease relevance of SMOX
- Spermine oxidase activity (SPO) was estimated by a bioassay of in vitro toxicity and did not necessarily correlate with BZO [1].
High impact information on SMOX
- Aminoguanidine, a known inhibitor of SPO, could prevent the cytotoxic effects of exogenously added spermidine in vitro [1].
- Plasma amine oxidase activities (benzylamine oxidase and spermine oxidase) were determined in the sera of a number of species of various ages [1].
- The results suggest that a cell line of hematogenous origin is susceptible to the cytotoxic effects of the products of oxidative deamination of spermidine by SPO, an enzyme present in perinatal bovine sera, and that these cytotoxic effects are potentiated in the presence of an oxygen-enriched environment in vitro [1].
References
- Spermidine cytotoxicity in vitro: effect of serum and oxygen tension. Hegre, O.D., Marshall, S., Hickey, G.E. In vitro. (1984) [Pubmed]
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