High impact information on Rab7

• This locates the site of Dor function to fusion of Golgi-derived vesicles with the large Rab7-positive endocytic compartments [1].
• Defective endosomal degradation in mutant alleles of dor results from a failure of Golgi-derived vesicles to fuse with morphologically arrested Rab7-positive large sized endosomes, which are, however, normally acidified and mature with wild-type kinetics [1].
• ALBR and fluid-phase-containing early endosomes subsequently fuse to yield a population of Rab7-positive late endosomes [2].
• Finally, our study shows that, in vivo, the Hh/Ptc complex is internalized in the Rab7-enriched lysosomal compartment in a Ptc-dependent manner without the co-receptor Smoothened (Smo) [3].

Biological context of Rab7

• Using high resolution imaging and immunofluorescence microscopy in these cells, products of eye color genes, deep-orange (dor) and carnation (car), are localized to large multivesicular Rab7-positive late endosomes containing Golgi-derived enzymes [1].

References