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Gene Review

Rab7  -  CG5915 gene product from transcript CG5915-RA

Drosophila melanogaster

Synonyms: AAF56218, CG5915, DRAB7, DRab7, Dm Rab7, ...
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High impact information on Rab7

  • This locates the site of Dor function to fusion of Golgi-derived vesicles with the large Rab7-positive endocytic compartments [1].
  • Defective endosomal degradation in mutant alleles of dor results from a failure of Golgi-derived vesicles to fuse with morphologically arrested Rab7-positive large sized endosomes, which are, however, normally acidified and mature with wild-type kinetics [1].
  • ALBR and fluid-phase-containing early endosomes subsequently fuse to yield a population of Rab7-positive late endosomes [2].
  • Finally, our study shows that, in vivo, the Hh/Ptc complex is internalized in the Rab7-enriched lysosomal compartment in a Ptc-dependent manner without the co-receptor Smoothened (Smo) [3].

Biological context of Rab7

  • Using high resolution imaging and immunofluorescence microscopy in these cells, products of eye color genes, deep-orange (dor) and carnation (car), are localized to large multivesicular Rab7-positive late endosomes containing Golgi-derived enzymes [1].


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