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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CPS1  -  carbamoyl-phosphate synthase 1, mitochondrial

Gallus gallus

 
 
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High impact information on CPS1

  • ARF 6, whose deduced amino acid sequence is identical with that of a putative chicken pseudogene (CPS1) except for a serine/threonine substitution, was different from other ARF species in size and deduced amino acid sequence [1].
  • A processed chicken pseudogene (CPS1) related to the ras oncogene superfamily [2].
  • This pattern of expression, and the presence of mutations in regions known to activate human c-ras genes to oncogenicity, suggest that CPS1 may represent a new oncogene family [2].
  • The chicken genome contains at least one other gene highly homologous to CPS1; at least one member of the CPS1 family is active, but only early in chicken development [2].
  • OTC was assigned to GGA1; ARG2 to GGA5; CPS1 to GGA7; and CRYD2 to GGA19 [3].
 

Biological context of CPS1

References

  1. Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. Tsuchiya, M., Price, S.R., Tsai, S.C., Moss, J., Vaughan, M. J. Biol. Chem. (1991) [Pubmed]
  2. A processed chicken pseudogene (CPS1) related to the ras oncogene superfamily. Alsip, G.R., Konkel, D.A. Nucleic Acids Res. (1986) [Pubmed]
  3. Assignment of CPS1, OTC, CRYD2, ARG2 and ASS genes to the chicken RH map. Shimogiri, T., Bosak, N., Morisson, M., Okamoto, S., Kawabe, K., Maeda, Y., Vignal, A., Yasue, H. Genet. Sel. Evol. (2004) [Pubmed]
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