Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

E(spl)malpha-BFM - Enhancer of split malpha, Bearded family...

Drosophila melanogaster

Synonyms: CG8337, DmelCG8337, Dmel\CG8337, E(spl) malpha, E(spl)ma, ...

Nagel, A.C. et al., Schlatter, R. et al.

Schlatter, Maier,

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Disease relevance of malpha

Neural hyperplasia induced by RNA interference with m4/malpha gene activity [1].

High impact information on malpha

Furthermore, a third member of the m4/malpha gene family, named bbu/tom, behaves differently with respect to RNA expression patterns, its regulation by Notch signaling and loss of function phenotypes [1].
Here, the E(spl)-C consists of one bHLH (mbeta) and one Brd family member (malpha) in a head to head arrangement [2].

Other interactions of malpha

Genes of the second class, the E(spl) m4/malpha family, antagonize this process if overexpressed [1].

References

Neural hyperplasia induced by RNA interference with m4/malpha gene activity. Nagel, A.C., Apidianakis, Y., Wech, I., Maier, D., Delidakis, C., Preiss, A. Mech. Dev. (2000) [Pubmed]
The Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee. Schlatter, R., Maier, D. BMC Evol. Biol. (2005) [Pubmed]

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