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Gene Review

E(spl)m7-HLH  -  Enhancer of split m7, helix-loop-helix

Drosophila melanogaster

Synonyms: CG8361, Dmel\CG8361, E(SPL)m7, E(spl) m7, E(spl)-M7, ...
 
 
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High impact information on HLHm7

  • This phenotype is suppressed by overexpression of E(spl)m7 and enhanced by overexpression of Dl [1].
  • This activity of E(spl)m7 and mgamma correlates with their ability to interact with proneural activators, through which they are probably tethered on target enhancers [2].
  • Yet, the efficacy of this antagonism is quite distinct: E(spl)mbeta has the strongest vein suppression effect, whereas E(spl)m8 and E(spl)m7 are the most active bristle suppressors [3].
  • The Enhancer of split complex [E(spl)-C] of Drosophila melanogaster is located in the 96F region of the third chromosome and comprises at least seven structurally related genes, HLH-m delta, HLH-m gamma, HLH-m beta, HLH-m3, HLH-m5, HLH-m7 and E(spl) [4].

References

 
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