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Gene Review

E(spl)m5-HLH  -  Enhancer of split m5, helix-loop-helix

Drosophila melanogaster

Synonyms: CG6096, Dmel\CG6096, E(spl) m5, E(spl) transcription unit m5, E(spl)-m5, ...
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High impact information on HLHm5

  • Second, the lack of N lateral signaling in these Su(H) mutant embryos was associated with a failure to express the m5 and m8 genes from the Enhancer of split Complex [E(spl)-C] [1].
  • Since m8 has a virtually identical pattern of expression as m4, m5 and m7, we have determined the sequence of these four transcripts [2].
  • The deduced protein products of m5, m7 and m8 exhibit extensive sequence homology with each other [2].
  • Using promoter and gene fusions with the lacZ gene, we determined the location of cis-acting sequences necessary for normal expression of two of the genes of the E(SPL)-C, E(spl) and HLH-m5 [3].
  • The Enhancer of split complex [E(spl)-C] of Drosophila melanogaster is located in the 96F region of the third chromosome and comprises at least seven structurally related genes, HLH-m delta, HLH-m gamma, HLH-m beta, HLH-m3, HLH-m5, HLH-m7 and E(spl) [4].

Biological context of HLHm5

  • Drosophila melanogaster casein kinase II interacts with and phosphorylates the basic helix-loop-helix proteins m5, m7, and m8 derived from the Enhancer of split complex [5].


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