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Gene Review:

E(spl)m5-HLH - Enhancer of split m5, helix-loop-helix

Drosophila melanogaster

Synonyms: CG6096, Dmel\CG6096, E(spl) m5, E(spl) transcription unit m5, E(spl)-m5, ...

Schrons, H. et al., Klämbt, C. et al., Kramatschek, B. et al., Lecourtois, M. et al., Trott, R.L. et al.

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High impact information on HLHm5

Second, the lack of N lateral signaling in these Su(H) mutant embryos was associated with a failure to express the m5 and m8 genes from the Enhancer of split Complex [E(spl)-C] [1].
Since m8 has a virtually identical pattern of expression as m4, m5 and m7, we have determined the sequence of these four transcripts [2].
The deduced protein products of m5, m7 and m8 exhibit extensive sequence homology with each other [2].
Using promoter and gene fusions with the lacZ gene, we determined the location of cis-acting sequences necessary for normal expression of two of the genes of the E(SPL)-C, E(spl) and HLH-m5 [3].
The Enhancer of split complex [E(spl)-C] of Drosophila melanogaster is located in the 96F region of the third chromosome and comprises at least seven structurally related genes, HLH-m delta, HLH-m gamma, HLH-m beta, HLH-m3, HLH-m5, HLH-m7 and E(spl) [4].

Biological context of HLHm5

Drosophila melanogaster casein kinase II interacts with and phosphorylates the basic helix-loop-helix proteins m5, m7, and m8 derived from the Enhancer of split complex [5].

References

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Lecourtois, M., Schweisguth, F. Genes Dev. (1995) [Pubmed]
Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster. Klämbt, C., Knust, E., Tietze, K., Campos-Ortega, J.A. EMBO J. (1989) [Pubmed]
Neuroectodermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes. Kramatschek, B., Campos-Ortega, J.A. Development (1994) [Pubmed]
The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells. Schrons, H., Knust, E., Campos-Ortega, J.A. Genetics (1992) [Pubmed]
Drosophila melanogaster casein kinase II interacts with and phosphorylates the basic helix-loop-helix proteins m5, m7, and m8 derived from the Enhancer of split complex. Trott, R.L., Kalive, M., Paroush, Z., Bidwai, A.P. J. Biol. Chem. (2001) [Pubmed]

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