Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MRX2 - mental retardation, X-linked 2 (non...

Homo sapiens

This record was replaced with 10084.

Sutherland, G.R. et al., Hu, L.J. et al., Gedeon, A. et al., Kozák, L. et al.

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Disease relevance of MRX2

Non-specific X-linked mental retardation: linkage analysis in MRX2 and MRX4 families revisited [1].
Linkage studies with the gene for an X-linked syndrome of mental retardation, microcephaly and spastic diplegia (MRX2) [2].

High impact information on MRX2

The linked region spanned chromosomal bands Xp21.1-Xp22.3, that is, the same portion of the X chromosome where MRX2 and MRX10-13 have been previously localised [3].
No evidence for linkage was determined using markers at several points along the remainder of the X chromosome, including the regions known to contain MRX1 and MRX2 [4].
In the MRX2 family, a lod score of 2.61 at theta = 0.05 had previously been obtained with DXS85 in Xp22 [1].
The maximum lod score was 2.10 at theta = 0.11 for DXYS1, assuming the possibly affected male carried the MRX2 gene [2].

Anatomical context of MRX2

A family in which a gene (MRX2) is segregating for an X-linked syndrome of mental retardation, short stature, microcephaly, brachycephaly, spastic diplegia, small testes and possible intra-uterine growth retardation is described [2].

References

Non-specific X-linked mental retardation: linkage analysis in MRX2 and MRX4 families revisited. Hu, L.J., Blumenfeld-Heyberger, S., Hanauer, A., Weissenbach, J., Mandel, J.L. Am. J. Med. Genet. (1994) [Pubmed]
Linkage studies with the gene for an X-linked syndrome of mental retardation, microcephaly and spastic diplegia (MRX2). Sutherland, G.R., Gedeon, A.K., Haan, E.A., Woodroffe, P., Mulley, J.C. Am. J. Med. Genet. (1988) [Pubmed]
Mapping of a gene for non-specific X linked mental retardation: evidence for linkage to chromosomal region Xp21.1-Xp22.3. Kozák, L., Chiurazzi, P., Genuardi, M., Pomponi, M.G., Zollino, M., Neri, G. J. Med. Genet. (1993) [Pubmed]
Localisation of the MRX3 gene for non-specific X linked mental retardation. Gedeon, A., Kerr, B., Mulley, J., Turner, G. J. Med. Genet. (1991) [Pubmed]

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