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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

disp  -  dispatched

Drosophila melanogaster

Synonyms: CG2019, Disp, Dmel\CG2019, Protein dispatched, anon-WO0146227.1
 
 
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High impact information on disp

  • We recovered multiple new alleles of hh and dispatched (disp) [1].
  • Loss-of-function mutations in cmn cause similar patterning defects to those caused by hh or dispatched (disp) mutations [1].
 

Associations of disp with chemical compounds

  • However, unlike disp, which is required for the release of the cholesterol-modified form of Hh, cmn regulates the activity of Hh in a manner that is independent of cholesterol modification [1].
  • We demonstrate that cholesterol modification of Hedgehog is responsible for its assembly in large punctate structures and apical sorting through the activity of the sterol-sensing domain-containing Dispatched protein [2].

References

  1. Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. Amanai, K., Jiang, J. Development (2001) [Pubmed]
  2. Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog. Gallet, A., Rodriguez, R., Ruel, L., Therond, P.P. Dev. Cell (2003) [Pubmed]
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