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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DISP1  -  dispatched homolog 1 (Drosophila)

Homo sapiens

Synonyms: DISPA, DKFZP434I0428, MGC13130, MGC16796, Protein dispatched homolog 1
 
 
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Disease relevance of DISP1

  • QT disp was improved among patients with successful reflow irrespective of which infarct artery was responsible for the acute myocardial infarction [1].
 

High impact information on DISP1

  • In the absence of Disp, cholesterol-modified but not cholesterol-free Hh is retained in these cells, indicating that Disp functions to release cholesterol-anchored Hh [2].
  • Micron-sized particles and thin films of sucrose octaacetate (SOA) were formed on silicon wafer substrate coupons from DISP at relatively low temperatures and pressures (< or = 6500 psi and < or = 60 degrees C) [3].
  • To develop an activity-based assay to differentiate between CYP1A1 and CYP1A2 expression in human hepatocytes, our previously published R warfarin assay (Drug Metab. Disp. (1995) 23, 1339-1345) was applied to TCDD (10 nM)-treated hepatocyte culture [4].
  • Mean action potential duration (APD) was increased under UA (287 ms. dispersion: 0.8 ms) when compared to NUA (285 ms, disp.: 3.2 ms) [5].
  • Firstly, we developed a multicolour fluorescent in situ hybridisation (FISH) assay using probes for the four major HPE genes and for two candidate genes (DISP1 and FOXA2) [6].
 

Associations of DISP1 with chemical compounds

  • Despite their opposite roles, Disp and Ptc share structural homology in the form of a sterol-sensing domain, suggesting that release and sequestration of cholesterol-modified Hh may be based on related molecular pathways [2].
  • Characterisation of a novel murine intestinal serine protease, DISP [7].

References

  1. The immediate and short-term effect of successful percutaneous coronary intervention on repolarization in acute myocardial infarction patients. Giedrimiene, D., Giri, S., White, C.M., Giedrimas, E., Kluger, J. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. (2002) [Pubmed]
  2. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Burke, R., Nellen, D., Bellotto, M., Hafen, E., Senti, K.A., Dickson, B.J., Basler, K. Cell (1999) [Pubmed]
  3. Deposition of small organic molecules by the displacement of two immiscible supercritical phases. Kim, J., Carbonell, R.G. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  4. Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2? Liu, N., Zhang, Q.Y., Vakharia, D., Dunbar, D., Kaminsky, L.S. Arch. Biochem. Biophys. (2001) [Pubmed]
  5. Sodium channel blockade enhances dispersion of the cardiac action potential duration. A computer simulation study. Müller, A., Dhein, S. Basic Res. Cardiol. (1993) [Pubmed]
  6. Multicolour FISH and quantitative PCR can detect submicroscopic deletions in holoprosencephaly patients with a normal karyotype. Bendavid, C., Haddad, B.R., Griffin, A., Huizing, M., Dubourg, C., Gicquel, I., Cavalli, L.R., Pasquier, L., Shanske, A.L., Long, R., Ouspenskaia, M., Odent, S., Lacbawan, F., David, V., Muenke, M. J. Med. Genet. (2006) [Pubmed]
  7. Characterisation of a novel murine intestinal serine protease, DISP. Shaw-Smith, C.J., Coffey, A.J., Leversha, M., Freeman, T.C., Bentley, D.R., Walters, J.R. Biochim. Biophys. Acta (2000) [Pubmed]
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