The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

rasp  -  CG11495 gene product from transcript...

Drosophila melanogaster

Synonyms: 7F21, CG11495, Dmel\CG11495, Protein central missing, Protein sightless, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on rasp

  • Our results suggest that Rasp-dependent acylation is necessary to generate a fully active Hh protein [1].
  • Loss-of-function mutations in cmn cause similar patterning defects to those caused by hh or dispatched (disp) mutations [2].
  • Moreover, cmn affects the expression of hh responsive genes but not of hh itself [2].
  • Like disp, cmn acts upstream of patched (ptc) and its activity is required only in the Hh secreting cells [2].
  • However, unlike disp, which is required for the release of the cholesterol-modified form of Hh, cmn regulates the activity of Hh in a manner that is independent of cholesterol modification [2].
 

Anatomical context of rasp

 

Other interactions of rasp

  • In addition, we identified a novel component in the hh pathway, which we name central missing (cmn) [2].

References

  1. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Micchelli, C.A., The, I., Selva, E., Mogila, V., Perrimon, N. Development (2002) [Pubmed]
  2. Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. Amanai, K., Jiang, J. Development (2001) [Pubmed]
  3. Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Miura, G.I., Buglino, J., Alvarado, D., Lemmon, M.A., Resh, M.D., Treisman, J.E. Dev. Cell (2006) [Pubmed]
 
WikiGenes - Universities