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Gene Review

arr  -  arrow

Drosophila melanogaster

Synonyms: Arr, BEST:CK00539, CG5912, CK00539, CT15575, ...
 
 
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High impact information on arr

  • In addition to the Frizzleds, members of the LRP family (represented by the arrow gene in Drosophila) are also necessary for Wnt signal transduction and have been postulated to act as co-receptors [1].
  • The aminotermini of LRP and Fz were reported to associate only in the presence of Wnt, implying that Wnt ligands form a trimeric complex with two different receptors [2].
  • We propose that Arrow (LRP) recruits Axin to the membrane, and that this interaction leads to Axin degradation [3].

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