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Gene Review

Lrp6  -  low density lipoprotein receptor-related...

Mus musculus

Synonyms: C030016K15Rik, Cd, Gw, LRP-6, Low-density lipoprotein receptor-related protein 6, ...
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High impact information on Lrp6


Biological context of Lrp6

  • Furthermore, the Lrp6 dysfunction in rs leads to delayed ossification at birth and to a low bone mass phenotype in adults [4].

Anatomical context of Lrp6


Regulatory relationships of Lrp6

  • These data suggest that Wnt7a acts through Lrp6 to regulate Lmx1b expression during dorsal specification [5].

Other interactions of Lrp6

  • The data are consistent with the view that Wnt7a acts through Lrp6 and the canonical Wnt signaling pathway during dorsal and posterior limb development in the mouse [5].


  1. An LDL-receptor-related protein mediates Wnt signalling in mice. Pinson, K.I., Brennan, J., Monkley, S., Avery, B.J., Skarnes, W.C. Nature. (2000) [Pubmed]
  2. Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6. MacDonald, B.T., Adamska, M., Meisler, M.H. Development (2004) [Pubmed]
  3. The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Kelly, O.G., Pinson, K.I., Skarnes, W.C. Development (2004) [Pubmed]
  4. Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Kokubu, C., Heinzmann, U., Kokubu, T., Sakai, N., Kubota, T., Kawai, M., Wahl, M.B., Galceran, J., Grosschedl, R., Ozono, K., Imai, K. Development (2004) [Pubmed]
  5. Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb. Adamska, M., Billi, A.C., Cheek, S., Meisler, M.H. Dev. Dyn. (2005) [Pubmed]
  6. Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants. Zhou, C.J., Pinson, K.I., Pleasure, S.J. J. Neurosci. (2004) [Pubmed]
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