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Gene Review

Axn  -  Axin

Drosophila melanogaster

Synonyms: 0442/30, APC, Axis inhibition protein, CG7926, D-Axin, ...
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High impact information on Axn


Biological context of Axn


Anatomical context of Axn


Associations of Axn with chemical compounds

  • In a yeast two-hybrid screen using the Drosophila Axin protein as a bait, we have identified a Drosophila homolog of CAP, a component of the glucose transport regulatory complex [6].

Physical interactions of Axn

  • It may permit the subsequent inactivation of the Axin complex by Wingless signaling [3].

Enzymatic interactions of Axn

  • In the absence of Wnt ligand, beta-catenin is phosphorylated by the Axin complex, which earmarks it for rapid degradation by the ubiquitin system [3].

Other interactions of Axn

  • Our results provide evidence for a function of Axin in the regulation of Armadillo that is different from its role as a scaffold for GSK3beta [7].
  • We propose that Arrow (LRP) recruits Axin to the membrane, and that this interaction leads to Axin degradation [8].


  1. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. Hamada, F., Tomoyasu, Y., Takatsu, Y., Nakamura, M., Nagai, S., Suzuki, A., Fujita, F., Shibuya, H., Toyoshima, K., Ueno, N., Akiyama, T. Science (1999) [Pubmed]
  2. Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan. Tolwinski, N.S., Wieschaus, E. Development (2001) [Pubmed]
  3. A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling. Cliffe, A., Hamada, F., Bienz, M. Curr. Biol. (2003) [Pubmed]
  4. A novel noncanonical Wnt pathway is involved in the regulation of the asymmetric B cell division in C. elegans. Wu, M., Herman, M.A. Dev. Biol. (2006) [Pubmed]
  5. Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos. Ruel, L., Stambolic, V., Ali, A., Manoukian, A.S., Woodgett, J.R. J. Biol. Chem. (1999) [Pubmed]
  6. Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex. Yamazaki, H., Nusse, R. Mech. Dev. (2002) [Pubmed]
  7. Notch synergizes with axin to regulate the activity of armadillo in Drosophila. Hayward, P., Balayo, T., Martinez Arias, A. Dev. Dyn. (2006) [Pubmed]
  8. Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. Tolwinski, N.S., Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S., Wieschaus, E. Dev. Cell (2003) [Pubmed]
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