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Gene Review

MMP13  -  matrix metallopeptidase 13 (collagenase 3)

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High impact information on MMP-13

  • In-vivo explants had increased collagen accumulation and strong MMP-13 expression at 4-8 weeks, but less activation (decreased expression of SMemb) and patchy endothelial cells at 16-20 weeks [1].
  • MMP-13 was overexpressed, mainly in fibroblasts and epithelial cells, while positivity for TRAIL and DR5 was detected on alveolar surfaces and in the vascular stroma [2].
  • Semiquantitative reverse transcription-polymerase chain reaction was performed for collagen types I, III, and V; matrix metalloproteinase-13 (MMP-13); and tissue inhibitor of metalloproteinase-1 for both injured and uninjured knee ligaments at 6 and 12 weeks after injury [3].

References

  1. Evolution of cell phenotype and extracellular matrix in tissue-engineered heart valves during in-vitro maturation and in-vivo remodeling. Rabkin, E., Hoerstrup, S.P., Aikawa, M., Mayer, J.E., Schoen, F.J. J. Heart Valve Dis. (2002) [Pubmed]
  2. Effects of exposure to fluoro-edenite fibre pollution on the respiratory system: an in vivo model. Martinez, G., Loreto, C., Rapisarda, V., Masumeci, G., Valentino, M., Carnazza, M.L. Histol. Histopathol. (2006) [Pubmed]
  3. Medial collateral ligament and partial anterior cruciate ligament transection: mRNA changes in uninjured ligaments of the sheep knee. Lo, I.K., Marchuk, L., Majima, T., Frank, C.B., Hart, D.A. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. (2003) [Pubmed]
 
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