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Gene Review:

ADORA3 - adenosine A3 receptor

Ovis aries

Linden, J. et al., Varani, K. et al.

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High impact information on LOC443330

Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution [1].
Among antagonists, the A3 adenosine receptor preferentially binds 8-phenylxanthines with acidic versus basic para-substituents (I-ABOPX > BW-A1433 > 1,3-dipropyl-8-sulfophenylxanthine = xanthine amine cogener) [1].
The A3 adenosine receptor is one of the four adenosine receptors which have thus far been identified [2].

Analytical, diagnostic and therapeutic context of LOC443330

Using the polymerase chain reaction, an A3 adenosine receptor has been cloned from the hypophysial par tuberalis of sheep [1].

References

Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution. Linden, J., Taylor, H.E., Robeva, A.S., Tucker, A.L., Stehle, J.H., Rivkees, S.A., Fink, J.S., Reppert, S.M. Mol. Pharmacol. (1993) [Pubmed]
Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors. Varani, K., Cacciari, B., Baraldi, P.G., Dionisotti, S., Ongini, E., Borea, P.A. Life Sci. (1998) [Pubmed]

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