The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

shark  -  SH2 ankyrin repeat kinase

Drosophila melanogaster

Synonyms: CG18247, Dmel\CG18247, Dtk7, SHARK, SYK/SHARK, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on shark

  • Thus, Shark regulates the JNK signaling pathway leading to Dpp expression in LE cells [1].
  • We have found that flies bearing a Shark tyrosine kinase gene mutation, shark(1), exhibit a DC-defective phenotype [1].
  • Furthermore, constitutive activation of the Dpp pathway throughout the epidermis fails to rescue the shark(1) DC defect, suggesting that Shark may function in additional pathways in the LE and/or lateral epithelium [1].
  • During Drosophila embryogenesis, Shark is expressed exclusively by ectodermally derived epithelia and is localized preferentially to the apical surface of these cells [2].
  • Consistent with these observations, Ddok mutant embryos exhibit decreased levels of tyrosine phosphorylated Shark at the cell periphery of LE and epidermal cells [3].

Biological context of shark

  • Using a yeast two-hybrid screen, the unique Drosophila homolog of the downstream of kinase (Dok) family, Ddok, was identified by its ability to bind Shark SH2 domains in a tyrosine phosphorylation-dependent fashion [3].
  • In cultured S2 embryonic cells, Ddok tyrosine phosphorylation is Src dependent; Shark associates with Ddok and Ddok localizes at the cell cortex, together with a portion of the Shark protein [3].


  1. The Drosophila shark tyrosine kinase is required for embryonic dorsal closure. Fernandez, R., Takahashi, F., Liu, Z., Steward, R., Stein, D., Stanley, E.R. Genes Dev. (2000) [Pubmed]
  2. Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia. Ferrante, A.W., Reinke, R., Stanley, E.R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Drosophila Dok is required for embryonic dorsal closure. Biswas, R., Stein, D., Stanley, E.R. Development (2006) [Pubmed]
WikiGenes - Universities