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Gene Review

rg  -  rugose

Drosophila melanogaster

Synonyms: A-kinase anchor protein 550, AKAP, AKAP 550, Akap550, CG15464, ...
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High impact information on rg

  • Cone cell loss in rg mutants is accompanied by enhanced Jun N-terminal kinase activity and, concomitantly, by a reduction of EGFR signalling activity [1].
  • Mutations in rugose promote cell type-specific apoptosis in the Drosophila eye [1].
  • A novel Drosophila A kinase anchor protein, Drosophila A kinase anchor protein 200 (DAKAP200), is predicted to be involved in routing, mediating, and integrating signals carried by cAMP, Ca(2+), and diacylglycerol (Li, Z., Rossi, E. A., Hoheisel, J. D., Kalderon, D., and Rubin, C. S. (1999) J. Biol. Chem. 274, 27191-27200) [2].
  • However, DAKAP550 is highly enriched and asymmetrically positioned in subpopulations of neurons and in apical portions of cells in gut and trachea [3].
  • The DAKAP550 gene was mapped to the 4F1.2 region of the X chromosome; flies that carry a deletion for this portion of the X chromosome lack DAKAP550 protein [3].

Biological context of rg

  • The cone cell phenotype is sensitive to the level of rugose gene function [4].
  • Mutations at the rugose locus (rg) result in a rough eye phenotype due to a disorganized retina and aberrant cone cell differentiation, which leads to reduction or complete loss of cone cells [4].
  • In this study, the pigment cell number in several ommatidia in rugose mutant eyes was analyzed and showed multiplication of secondary pigment cells in the null mutation [5].

Anatomical context of rg


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