Disease relevance of Optic Lobe

• Neurotensin-like immunoreactivity in locust supraesophageal ganglion and optic lobes [1].
• Acute hypoxic hypoxia alters GABA(A) receptor modulation by allopregnanolone and pentobarbital in embryonic chick optic lobe [2].
• Expression of tetanus toxin light chain (which cleaves neuronal synaptobrevin) and genetic mosaics were used to analyze neuropil pattern formation and levels of selected neural adhesion molecules in the optic lobe [3].

High impact information on Optic Lobe

• In this report I document some basic properties of the histamine receptors present on large monopolar cells isolated from blowfly optic lobes [4].
• In tangential cells of crayfish optic lobes, a hyperpolarizing, biphasic synaptic potential is produced by the concurrent action of acetylcholine and gamma aminobutyric acid (GABA) [5].
• Weak repo alleles were viable but affected glia in the optic lobe, resulting in a reversal in polarity of the electrophysiological to light in the adult [6].
• Thereafter, beta-galactosidase activity is undetectable until the pupal stage when the prothoracic gland-corpora allata and the optic lobes are beta-galactosidase positive [7].
• We demonstrate that Gcm and Gcm2 are expressed in both glial and neuronal precursors within the optic lobe [8].

Biological context of Optic Lobe

• Here, we show that the JAB1/CSN5 subunit of the COP9 signalosome complex is expressed in R cells, accumulates in the developing optic lobe neuropil, and through the analysis of a unique set of missense mutations, is required in R cells to induce lamina glial cell migration [9].
• At later stages of embryogenesis, ptc is expressed in the primordia of epithelial placodes of a specific portion of the brain, the optic lobes [10].
• During metamorphosis, a temporal relationship between the morphogenesis of the optic lobe and expression of AChR64B transcripts was observed [11].
• Lowering Dpp levels (in dpp heterozygotes or hypomorphic alleles) results in a 'cyclops' phenotype, where mid-dorsal head epidermis is transformed into dorsolateral structures, i.e. eye/optic lobe tissue, which causes a continuous visual primordium across the dorsal midline [12].
• A 7.4 kb 5' flanking sequence directed beta-galactosidase expression in the adult optic lobes and other well-defined CNS structures with a pattern very similar to the distribution of endogenous ChAT protein [13].

Anatomical context of Optic Lobe

• In addition, gil mutants show drastic effects on photoreceptor axon guidance and optic lobe development [14].
• Benzodiazepine recognition sites labeled "in vitro" with [3H]flunitrazepam ([3H]FNT) were present in highest concentration in the optic lobe and in lowest concentration in the medulla oblongata and spinal cord [15].
• These phenotypic abnormalities reinforce the notion that nonA's ubiquitous expression has its most important consequences in the optic lobes, the thoracic ganglia, or both, depending in part on the nonA allele [16].
• We conclude that synaptosomes from the squid optic lobe posses intact membranes and mechanisms to regulate intrasynaptosomal free [Ca(2+)], as well as caffeine sensitive Ca(2+) stores [17].
• 2. MG 624, F3, F3A and F3B inhibited of 125I-alphaBungarotoxin (alphaBgtx) binding to neuronal chick optic lobe (COL) membranes, with nM affinity, but inhibited 125I-alphaBgtx binding to TE671 cell-expressed muscle-type AChR only at much higher concentrations [18].

Associations of Optic Lobe with chemical compounds

• Nitric oxide and cyclic GMP regulate retinal patterning in the optic lobe of Drosophila [19].
• Nicotinic acetylcholine receptor from chick optic lobe [20].
• A Drosophila receptor tyrosine phosphatase expressed in the embryonic CNS and larval optic lobes is a member of the set of proteins bearing the "HRP" carbohydrate epitope [21].
• Histamine-gated chloride channels have been identified in insect optic lobes [22].
• Surprisingly, systemic Dex delivery appeared to potentiate CNS damage, which was preceded by petechial hemorrhaging in the optic lobes [23].

Gene context of Optic Lobe

• Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe development [24].
• In the adult head, in situ hybridization analysis reveals that per and Crg-1 have similar expression patterns in the eyes and optic lobes [25].
• Rapgap1 is expressed at high levels in the developing photoreceptor cells and in the optic lobe [26].
• Expression of tll is normally confined to the optic lobe primordium, whereas ato appears in a subset of Bolwig's organ cells that we call Bolwig's organ founders [27].
• Regulatory genes that are required for eye/optic lobe fate, including sine oculis (so) and eyes absent (eya), are turned on in their respective domains by Dpp [12].

Analytical, diagnostic and therapeutic context of Optic Lobe

• Effect of unilateral visual deprivation and visual stimulation on the activities of alkaline phosphatase, acid phosphatase, Na-+ --K-+ activated Mg-2-+ catalysed adenosine triphosphatase and on the content of sodium and potassium ions of the optic lobe of adult pigeon [28].
• In the present study, we have examined the binding of a monoclonal antibody to 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in the compound eye and optic lobe of the crab Ucides cordatus using both light and electron microscopy [29].
• Microinjection of serotonin or a serotonin-receptor agonist, quipazine, into the optic lobe caused a dose- and time-dependent inhibition of spontaneous and light-induced responses, mimicking the day state [30].
• The concentrations of NPY immunoreactive material in acetic acid extracts of locust brain, optic lobes, thoracic ganglia, ovaries and midguts was measured using a specific radioimmunoassay technique [31].
• Through in vivo observations of the brain surface (optic lobes) of rainbow trout (Oncorhynchus mykiss) with epi-illumination microscopy, we show that application of acetylcholine (ACh) to the brain surface induces an increase in cerebral blood flow velocity that can be completely blocked by the NO synthase inhibitor NG-nitro-L-arginine [32].

References