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Gene Review:

dlc - dynein light chain

Ciona intestinalis

Nomura, M. et al., Dey, C.S. et al., Padma, P. et al.

Nomura, Inaba, Morisawa,

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High impact information on DLC

LRR37 is different from the LRR outer arm dynein light chain reported in Chlamydomonas and sea urchin flagella, and thus represents a novel axonemal LRR protein [1].
A high molecular mass dynein ATPase polypeptide and a 18-20 kDa dynein light chain of Ciona sperm flagella are phosphorylated during in vivo activation of motility or in vitro activation of motility by incubation with cyclic AMP [2].
During in vivo or in vitro activation of sperm motility by SAAF or cAMP, a 26 kDa axonemal protein and 21 kDa dynein light chain were phosphorylated, respectively, suggesting the involvement of PKA-dependent phosphorylation of these proteins in sperm activation [3].

References

Identification of a novel leucine-rich repeat protein as a component of flagellar radial spoke in the Ascidian Ciona intestinalis. Padma, P., Satouh, Y., Wakabayashi, K., Hozumi, A., Ushimaru, Y., Kamiya, R., Inaba, K. Mol. Biol. Cell (2003) [Pubmed]
Activation of Ciona sperm motility: phosphorylation of dynein polypeptides and effects of a tyrosine kinase inhibitor. Dey, C.S., Brokaw, C.J. J. Cell. Sci. (1991) [Pubmed]
Cyclic AMP- and calmodulin-dependent phosphorylation of 21 and 26 kda proteins in axoneme is a prerequisite for SAAF-induced motile activation in ascidian spermatozoa. Nomura, M., Inaba, K., Morisawa, M. Dev. Growth Differ. (2000) [Pubmed]

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