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MeSH Review

Sperm Motility

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Disease relevance of Sperm Motility


High impact information on Sperm Motility

  • For the 95 kd protein, the level of immunoreactivity is not related to sperm motility but is enhanced by both capacitation and sperm interaction with solubilized ZP proteins [6].
  • Creatine kinase inactivation led to an inhibition of coupled, but not uncoupled, respiration and affected the pattern of sperm motility as predicted for the disruption of an obligatory link in P transport [7].
  • On all measures of secondary-sex-organ and testicular function, heroin addicts appeared to fall between the methadone and control subjects, but, with the exception of sperm motility, the deviation from control values did not reach statisitcal significance [8].
  • Smok kinases are components of a signal cascade which may control sperm motility [9].
  • In vivo antisense experiments show that suppressed expression of Bin1b results in reduced binding of Bin1b to caput sperm and in considerable attenuation of sperm motility and progressive movement [10].

Chemical compound and disease context of Sperm Motility


Biological context of Sperm Motility


Anatomical context of Sperm Motility


Associations of Sperm Motility with chemical compounds


Gene context of Sperm Motility


Analytical, diagnostic and therapeutic context of Sperm Motility


  1. Reversible male infertility due to sulphasalazine: studies in man and rat. O'Moráin, C., Smethurst, P., Doré, C.J., Levi, A.J. Gut (1984) [Pubmed]
  2. Induction of reversible infertility in male rats by oral ornidazole and its effects on sperm motility and epididymal secretions. Oberländer, G., Yeung, C.H., Cooper, T.G. J. Reprod. Fertil. (1994) [Pubmed]
  3. Effects of pentoxifylline in the hamster zona-free oocyte spermatozoa penetration assay and on spermatozoa transmembrane migration motility. Chiang, P.H., Tsai, E.M., Shen, M.R., Chang, J.C., Lin, Y.C., Huang, C.H., Chiang, C.P. Eur. Urol. (1992) [Pubmed]
  4. Relationship of follicle number, serum estradiol, and other factors to birth rate and multiparity in human menopausal gonadotropin-induced intrauterine insemination cycles. Dickey, R.P., Olar, T.T., Taylor, S.N., Curole, D.N., Rye, P.H., Matulich, E.M. Fertil. Steril. (1991) [Pubmed]
  5. The contribution of the toxicity of a glycerol-egg yolk-citrate cryopreservative to the decline in human sperm motility during cryopreservation. McLaughlin, E.A., Ford, W.C., Hull, M.G. J. Reprod. Fertil. (1992) [Pubmed]
  6. 95 kd sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding. Leyton, L., Saling, P. Cell (1989) [Pubmed]
  7. Metabolite channeling: a phosphorylcreatine shuttle to mediate high energy phosphate transport between sperm mitochondrion and tail. Tombes, R.M., Shapiro, B.M. Cell (1985) [Pubmed]
  8. Function of the male sex organs in heroin and methadone users. Cicero, T.J., Bell, R.D., Wiest, W.G., Allison, J.H., Polakoski, K., Robins, E. N. Engl. J. Med. (1975) [Pubmed]
  9. A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance. Herrmann, B.G., Koschorz, B., Wertz, K., McLaughlin, K.J., Kispert, A. Nature (1999) [Pubmed]
  10. An epididymis-specific beta-defensin is important for the initiation of sperm maturation. Zhou, C.X., Zhang, Y.L., Xiao, L., Zheng, M., Leung, K.M., Chan, M.Y., Lo, P.S., Tsang, L.L., Wong, H.Y., Ho, L.S., Chung, Y.W., Chan, H.C. Nat. Cell Biol. (2004) [Pubmed]
  11. Effect of STS 557 on semen composition, fertility and sexual behaviour of male rabbits. Freund, H., Hesse, G., Oettel, M. Contraception. (1980) [Pubmed]
  12. Effect of oral administration of carbofuran on male reproductive system of rat. Pant, N., Prasad, A.K., Srivastava, S.C., Shankar, R., Srivastava, S.P. Human & experimental toxicology. (1995) [Pubmed]
  13. Effects of acrylamide on rodent reproductive performance. Tyl, R.W., Friedman, M.A. Reprod. Toxicol. (2003) [Pubmed]
  14. Toxicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344 rats and B6C3F(1) mice. Melnick, R.L., Elwell, M.R., Roycroft, J.H., Chou, B.J., Ragan, H.A., Miller, R.A. Toxicology (1996) [Pubmed]
  15. Fructose, prostatic acid phosphatase and zinc levels in the seminal plasma of varicoceles. Andò, S., Carpino, A., Buffone, M., Maggiolini, M., Giacchetto, C., Seidita, F. Int. J. Fertil. (1990) [Pubmed]
  16. Mechanisms of endocrine dysfunction in patients with testicular cancer. Morrish, D.W., Venner, P.M., Siy, O., Barron, G., Bhardwaj, D., Outhet, D. J. Natl. Cancer Inst. (1990) [Pubmed]
  17. erythro-9-[3-(2-Hydroxynonyl)]adenine is an effective inhibitor of cell motility and actin assembly. Schliwa, M., Ezzell, R.M., Euteneuer, U. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  18. An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail. Turner, R.M., Johnson, L.R., Haig-Ladewig, L., Gerton, G.L., Moss, S.B. J. Biol. Chem. (1998) [Pubmed]
  19. Isolation and properties of Gas8, a growth arrest-specific gene regulated during male gametogenesis to produce a protein associated with the sperm motility apparatus. Yeh, S.D., Chen, Y.J., Chang, A.C., Ray, R., She, B.R., Lee, W.S., Chiang, H.S., Cohen, S.N., Lin-Chao, S. J. Biol. Chem. (2002) [Pubmed]
  20. Increased phosphorylation of AKAP by inhibition of phosphatidylinositol 3-kinase enhances human sperm motility through tail recruitment of protein kinase A. Luconi, M., Carloni, V., Marra, F., Ferruzzi, P., Forti, G., Baldi, E. J. Cell. Sci. (2004) [Pubmed]
  21. Involvement of zinc in the regulation of pHi, motility, and acrosome reactions in sea urchin sperm. Clapper, D.L., Davis, J.A., Lamothe, P.J., Patton, C., Epel, D. J. Cell Biol. (1985) [Pubmed]
  22. Positive selection on protein-length in the evolution of a primate sperm ion channel. Podlaha, O., Zhang, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  23. Sodium bicarbonate in seminal plasma stimulates the motility of mammalian spermatozoa through direct activation of adenylate cyclase. Okamura, N., Tajima, Y., Soejima, A., Masuda, H., Sugita, Y. J. Biol. Chem. (1985) [Pubmed]
  24. Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility. Schuh, K., Cartwright, E.J., Jankevics, E., Bundschu, K., Liebermann, J., Williams, J.C., Armesilla, A.L., Emerson, M., Oceandy, D., Knobeloch, K.P., Neyses, L. J. Biol. Chem. (2004) [Pubmed]
  25. Calcium ion is the key regulator of human sperm function. Hong, C.Y., Chiang, B.N., Turner, P. Lancet (1984) [Pubmed]
  26. Potassium ion influx and Na+,K+-ATPase activity are required for the hamster sperm acrosome reaction. Mrsny, R.J., Meizel, S. J. Cell Biol. (1981) [Pubmed]
  27. Effects of protease inhibitors and substrates on motility of mammalian spermatozoa. de Lamirande, E., Gagnon, C. J. Cell Biol. (1986) [Pubmed]
  28. Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. Yan, W., Assadi, A.H., Wynshaw-Boris, A., Eichele, G., Matzuk, M.M., Clark, G.D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  29. Membrane hyperpolarization removes inactivation of Ca2+ channels, leading to Ca2+ influx and subsequent initiation of sperm motility in the common carp. Krasznai, Z., Marian, T., Izumi, H., Damjanovich, S., Balkay, L., Tron, L., Morisawa, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  30. Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. Yu, Y.E., Zhang, Y., Unni, E., Shirley, C.R., Deng, J.M., Russell, L.D., Weil, M.M., Behringer, R.R., Meistrich, M.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  31. Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility. Miki, K., Qu, W., Goulding, E.H., Willis, W.D., Bunch, D.O., Strader, L.F., Perreault, S.D., Eddy, E.M., O'Brien, D.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  32. Cyclic GMP-specific phosphodiesterase-5 regulates motility of sea urchin spermatozoa. Su, Y.H., Vacquier, V.D. Mol. Biol. Cell (2006) [Pubmed]
  33. Synthesis and secretion of angiotensin II by the prostate gland in vitro. O'Mahony, O.A., Barker, S., Puddefoot, J.R., Vinson, G.P. Endocrinology (2005) [Pubmed]
  34. Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene. Hawthorne, S.K., Goodarzi, G., Bagarova, J., Gallant, K.E., Busanelli, R.R., Olend, W.J., Kleene, K.C. Genomics (2006) [Pubmed]
  35. Incorporating lipids into boar sperm decreases chilling sensitivity but not capacitation potential. He, L., Bailey, J.L., Buhr, M.M. Biol. Reprod. (2001) [Pubmed]
  36. The stimulatory role of estrogen on sperm motility in the male golden hamster (Mesocricetus auratus). Jin, W., Arai, K.Y., Watanabe, G., Suzuki, A.K., Takahashi, S., Taya, K. J. Androl. (2005) [Pubmed]
  37. Motility and eosin uptake of formaldehyde-treated ram spermatozoa. Osinowo, O.A., Bale, J.O., Oyedipe, E.O., Eduvie, L.O. J. Reprod. Fertil. (1982) [Pubmed]
  38. Hyper-osmotic condition enhances protein tyrosine phosphorylation and zona pellucida binding capacity of human sperm. Liu, D.Y., Clarke, G.N., Baker, H.W. Hum. Reprod. (2006) [Pubmed]
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