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Gene Review:

MAPk-Ak2 - MAP kinase activated protein-kinase-2

Drosophila melanogaster

Synonyms: CG3086, DmMAPKAPK-2, Dmel\CG3086, MAP kinase-activated protein kinase 2, MAPK-activated protein kinase 2, ...

Larochelle, S. et al.

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High impact information on MAPk-Ak2

As in mammalian MAPKAPK-2, the Dm MAPKAPK-2 possesses a MAPK phosphorylation site and a nuclear targeting sequence located C-terminal to the catalytic domain [1].
The Drosophila melanogaster homolog of the mammalian MAPK-activated protein kinase-2 (MAPKAPK-2) lacks a proline-rich N-terminus [1].
Dm MAPKAPK-2 is located at cytological position 5D in the Dm genome [1].

Biological context of MAPk-Ak2

The stress-induced activation of MAPKAPK-2, in turn, results in the phosphorylation of small heat-shock proteins (Hsp) [1].

References

The Drosophila melanogaster homolog of the mammalian MAPK-activated protein kinase-2 (MAPKAPK-2) lacks a proline-rich N-terminus. Larochelle, S., Suter, B. Gene (1995) [Pubmed]

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