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Gene Review

MAPKAPK3  -  mitogen-activated protein kinase-activated...

Homo sapiens

Synonyms: 3PK, 3pK, Chromosome 3p kinase, MAP kinase-activated protein kinase 3, MAPK-activated protein kinase 3, ...
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Disease relevance of MAPKAPK3


High impact information on MAPKAPK3

  • The other appeared to be MAPKAP kinase 3; however, it could not be excluded that also other p38-dependent kinases contributed [3].
  • Here we show that 3pK is activated in vivo by the growth inducers serum and tetradecanoyl phorbol acetate in promyelocytic HL60 cells and transiently transfected embryonic kidney 293 cells [4].
  • Activation or overexpression of 3pK resulted in phosphorylation of Bmi1 and other PcG members and their dissociation from chromatin [5].
  • MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1 [5].
  • E47 is a phosphoprotein, and we identified 3pK and MK2 as E47 kinases in vitro [6].

Biological context of MAPKAPK3


Anatomical context of MAPKAPK3


Associations of MAPKAPK3 with chemical compounds


Regulatory relationships of MAPKAPK3


Other interactions of MAPKAPK3


Analytical, diagnostic and therapeutic context of MAPKAPK3


  1. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. Sithanandam, G., Latif, F., Duh, F.M., Bernal, R., Smola, U., Li, H., Kuzmin, I., Wixler, V., Geil, L., Shrestha, S. Mol. Cell. Biol. (1996) [Pubmed]
  2. Absence of mutations in the coding sequence of the potential tumor suppressor 3pK in metastatic melanoma. Houben, R., Becker, J.C., Rapp, U.R. Journal of carcinogenesis [electronic resource]. (2005) [Pubmed]
  3. 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. Werz, O., Klemm, J., Samuelsson, B., Rådmark, O. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. Ludwig, S., Engel, K., Hoffmeyer, A., Sithanandam, G., Neufeld, B., Palm, D., Gaestel, M., Rapp, U.R. Mol. Cell. Biol. (1996) [Pubmed]
  5. MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. Voncken, J.W., Niessen, H., Neufeld, B., Rennefahrt, U., Dahlmans, V., Kubben, N., Holzer, B., Ludwig, S., Rapp, U.R. J. Biol. Chem. (2005) [Pubmed]
  6. Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. Neufeld, B., Grosse-Wilde, A., Hoffmeyer, A., Jordan, B.W., Chen, P., Dinev, D., Ludwig, S., Rapp, U.R. J. Biol. Chem. (2000) [Pubmed]
  7. Human cell lines engineered for tetracycline-regulated expression of tumor suppressor candidate genes from a frequently affected chromosomal region, 3p21. Protopopov, A.I., Li, J., Winberg, G., Gizatullin, R.Z., Kashuba, V.I., Klein, G., Zabarovsky, E.R. The journal of gene medicine. (2002) [Pubmed]
  8. Developmental regulation of mitogen-activated protein kinase-activated kinases-2 and -3 (MAPKAPK-2/-3) in vivo during corpus luteum formation in the rat. Maizels, E.T., Mukherjee, A., Sithanandam, G., Peters, C.A., Cottom, J., Mayo, K.E., Hunzicker-Dunn, M. Mol. Endocrinol. (2001) [Pubmed]
  9. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. Clifton, A.D., Young, P.R., Cohen, P. FEBS Lett. (1996) [Pubmed]
  10. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Eyers, C.E., McNeill, H., Knebel, A., Morrice, N., Arthur, S.J., Cuenda, A., Cohen, P. Biochem. J. (2005) [Pubmed]
  11. Mapping of a new MAP kinase activated protein kinase gene (3PK) to human chromosome band 3p21.2 and ordering of 3PK and two cosmid markers in the 3p22-p21 tumour-suppressor region by two-colour fluorescence in situ hybridization. Szeles, A., Bajalica-Lagercrantz, S., Lindblom, A., Lushnikova, T., Kashuba, V.I., Imreh, S., Nordenskjöld, M., Klein, G., Zabarovsky, E.R. Chromosome Res. (1996) [Pubmed]
  12. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. McLaughlin, M.M., Kumar, S., McDonnell, P.C., Van Horn, S., Lee, J.C., Livi, G.P., Young, P.R. J. Biol. Chem. (1996) [Pubmed]
  13. Dynamic changes in mitogen-activated protein kinase (MAPK) activities in the corpus luteum of the bonnet monkey (Macaca radiata) during development, induced luteolysis, and simulated early pregnancy: a role for p38 MAPK in the regulation of luteal function. Yadav, V.K., Medhamurthy, R. Endocrinology (2006) [Pubmed]
  14. Gene activity changes in ischemically preconditioned rabbit heart gene: discovery array study. Simkhovich, B.Z., Abdishoo, S., Poizat, C., Hale, S.L., Kedes, L.H., Kloner, R.A. Heart disease (Hagerstown, Md.) (2002) [Pubmed]
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