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Gene Review

luzp1  -  leucine zipper protein 1

Xenopus laevis

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High impact information on luzp1

  • We also injected leucine zipper peptides individually into Xenopus oocytes to study whether they would interfere with the activity of the Fos/Jun heterodimer in vivo [1].
  • A long open reading frame (ORF) encodes the CCHC motif conserved in retroviral gag proteins and leucine zipper motif capable of forming the coiled-coil [2].
  • The human SOX13 gene spans >15.5kb of genomic DNA and is composed of 14 exons with introns interrupting regions encoding the HMG DNA binding domain and the leucine zipper/glutamine-rich dimerisation domain [3].
  • A similar role has been reported for the proto-oncogene c-myc, another leucine-zipper-containing transcription factor, in tissue culture cell systems [4].
  • The protein sequence deduced from the cDNA, contains the two characteristic features of EF-1 delta protein, the leucine-zipper domain and the guanine-nucleotide exchange domain [5].

Associations of luzp1 with chemical compounds


Other interactions of luzp1


  1. An efficient screening assay for the rapid and precise determination of affinities between leucine zipper domains. Pernelle, C., Clerc, F.F., Dureuil, C., Bracco, L., Tocque, B. Biochemistry (1993) [Pubmed]
  2. A novel family of retrotransposons in Xenopus with a developmentally regulated expression. Shim, S., Lee, S.K., Han, J.K. Genesis (2000) [Pubmed]
  3. Genomic characterisation and fine mapping of the human SOX13 gene. Argentaro, A., Olsson, J., Critcher, R., McDowall, S.G., Harley, V.R. Gene (2000) [Pubmed]
  4. Temporal and spatial regulation of a putative transcriptional repressor implicates it as playing a role in thyroid hormone-dependent organ transformation. Ishizuya-Oka, A., Ueda, S., Shi, Y.B. Dev. Genet. (1997) [Pubmed]
  5. The guanine-nucleotide-exchange complex (EF-1 beta gamma delta) of elongation factor-1 contains two similar leucine-zipper proteins EF-1 delta, p34 encoded by EF-1 delta 1 and p36 encoded by EF-1 delta 2. Minella, O., Mulner-Lorillon, O., Poulhe, R., Bellé, R., Cormier, P. Eur. J. Biochem. (1996) [Pubmed]
  6. Cloning and expression of Xenopus laevis xSox12 cDNA. Komatsu, N., Hiraoka, Y., Shiozawa, M., Ogawa, M., Aiso, S. Biochim. Biophys. Acta (1996) [Pubmed]
  7. Xenopus Germes encodes a novel germ plasm-associated transcript. Berekelya, L.A., Ponomarev, M.B., Luchinskaya, N.N., Belyavsky, A.V. Gene Expr. Patterns (2003) [Pubmed]
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