Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

papd4a - PAP associated domain containing 4 a

Xenopus laevis

Synonyms: gld2, xGLD-2

Rouhana, L. et al., Kwak, J.E. et al.

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High impact information on GLD2

The polyadenylation activity of GLD-2 is stimulated by physical interaction with an RNA binding protein, GLD-3 [1].
To test whether GLD-3 might stimulate GLD-2 by recruiting it to RNA, we tethered C. elegans GLD-2 to mRNAs in Xenopus oocytes by using MS2 coat protein [1].
In the hippocampus, mouse GLD2 mRNA colocalizes with CPEB1 and Pumilio1 mRNAs, both of which are likely involved in synaptic plasticity [2].

Biological context of GLD2

We suggest that mammalian GLD2 poly(A) polymerases are important in synaptic translation, and in polyadenylation throughout the soma [2].

Anatomical context of GLD2

We propose that at least two distinct polyadenylation complexes exist in Xenopus oocytes, one of which contains GLD2; the other, maskin and Pumilio [2].

References

Mammalian GLD-2 homologs are poly(A) polymerases. Kwak, J.E., Wang, L., Ballantyne, S., Kimble, J., Wickens, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Vertebrate GLD2 poly(A) polymerases in the germline and the brain. Rouhana, L., Wang, L., Buter, N., Kwak, J.E., Schiltz, C.A., Gonzalez, T., Kelley, A.E., Landry, C.F., Wickens, M. RNA (2005) [Pubmed]

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