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Gene Review:

crk - v-crk avian sarcoma virus CT10 oncogene...

Xenopus (Silurana) tropicalis

Synonyms: crkii, crko, v-crk

Evans, E.K. et al., Smith, J.J. et al.

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High impact information on crk

Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts [1].

Biological context of crk

The ability to undergo apoptosis can be restored to these extracts by addition of recombinant crk protein [2].

Associations of crk with chemical compounds

Here we show that addition of a recombinant protein containing the phosphotyrosine binding (SH2) domain from the adaptor protein crk, but not those derived from a panel of other signaling proteins, can prevent apoptosis in the Xenopus egg extract system [2].

References

Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. Smith, J.J., Evans, E.K., Murakami, M., Moyer, M.B., Moseley, M.A., Woude, G.V., Kornbluth, S. J. Cell Biol. (2000) [Pubmed]
Crk is required for apoptosis in Xenopus egg extracts. Evans, E.K., Lu, W., Strum, S.L., Mayer, B.J., Kornbluth, S. EMBO J. (1997) [Pubmed]

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AgaP_AGAP009499	Anopheles gambiae str. PEST
CRK	Bos taurus
ced-2	Caenorhabditis elegans
CRK	Canis lupus familiaris
crk	Danio rerio
Crk	Drosophila melanogaster
CRK	Gallus gallus
CRK	Homo sapiens
LOC701185	Macaca mulatta
Crk	Mus musculus
CRK	Pan troglodytes
Crk	Rattus norvegicus

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