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Gene Review

crk  -  v-crk avian sarcoma virus CT10 oncogene...

Xenopus (Silurana) tropicalis

Synonyms: crkii, crko, v-crk
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High impact information on crk


Biological context of crk

  • The ability to undergo apoptosis can be restored to these extracts by addition of recombinant crk protein [2].

Associations of crk with chemical compounds

  • Here we show that addition of a recombinant protein containing the phosphotyrosine binding (SH2) domain from the adaptor protein crk, but not those derived from a panel of other signaling proteins, can prevent apoptosis in the Xenopus egg extract system [2].


  1. Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. Smith, J.J., Evans, E.K., Murakami, M., Moyer, M.B., Moseley, M.A., Woude, G.V., Kornbluth, S. J. Cell Biol. (2000) [Pubmed]
  2. Crk is required for apoptosis in Xenopus egg extracts. Evans, E.K., Lu, W., Strum, S.L., Mayer, B.J., Kornbluth, S. EMBO J. (1997) [Pubmed]
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