Gene Review:
CRK - v-crk avian sarcoma virus CT10 oncogene...
Homo sapiens
Synonyms:
Adapter molecule crk, CRKII, Proto-oncogene c-Crk, p38
Parameswaran,
Hall,
Bock,
Sparks,
Gallo,
Spielman,
Turner,
Yang,
Zhang,
Pasumarthy,
Zhang,
Warnock,
Schnermann,
- C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Tanaka, S., Morishita, T., Hashimoto, Y., Hattori, S., Nakamura, S., Shibuya, M., Matuoka, K., Takenawa, T., Kurata, T., Nagashima, K. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells. Zhang, T., Li, Y., Wang, Y.J., Wang, X., Young, M., Douglas, S.D., Ho, W.Z. Antiviral Res. (2007)
- Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas. Miller, C.T., Chen, G., Gharib, T.G., Wang, H., Thomas, D.G., Misek, D.E., Giordano, T.J., Yee, J., Orringer, M.B., Hanash, S.M., Beer, D.G. Oncogene (2003)
- CRK proto-oncogene maps to human chromosome band 17p13. Fioretos, T., Heisterkamp, N., Groffen, J., Benjes, S., Morris, C. Oncogene (1993)
- Proline isomerization of histone h3 regulates lysine methylation and gene expression. Nelson, C.J., Santos-Rosa, H., Kouzarides, T. Cell (2006)
- Inhibition of MAPK stimulates the Ca2+-dependent big-conductance K channels in cortical collecting duct. Li, D., Wang, Z., Sun, P., Jin, Y., Lin, D.H., Hebert, S.C., Giebisch, G., Wang, W.H. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins. Barber, D.L., Mason, J.M., Fukazawa, T., Reedquist, K.A., Druker, B.J., Band, H., D'Andrea, A.D. Blood (1997)
- Amplification, up-regulation and over-expression of C3G (CRK SH3 domain-binding guanine nucleotide-releasing factor) in non-small cell lung cancers. Hirata, T., Nagai, H., Koizumi, K., Okino, K., Harada, A., Onda, M., Nagahata, T., Mikami, I., Hirai, K., Haraguchi, S., Jin, E., Kawanami, O., Shimizu, K., Emi, M. J. Hum. Genet. (2004)
- RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Hu, H., Bliss, J.M., Wang, Y., Colicelli, J. Curr. Biol. (2005)
- CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. Salgia, R., Uemura, N., Okuda, K., Li, J.L., Pisick, E., Sattler, M., de Jong, R., Druker, B., Heisterkamp, N., Chen, L.B. J. Biol. Chem. (1995)
- Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. Matsuda, M., Ota, S., Tanimura, R., Nakamura, H., Matuoka, K., Takenawa, T., Nagashima, K., Kurata, T. J. Biol. Chem. (1996)
- Two species of human CRK cDNA encode proteins with distinct biological activities. Matsuda, M., Tanaka, S., Nagata, S., Kojima, A., Kurata, T., Shibuya, M. Mol. Cell. Biol. (1992)
- DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Hasegawa, H., Kiyokawa, E., Tanaka, S., Nagashima, K., Gotoh, N., Shibuya, M., Kurata, T., Matsuda, M. Mol. Cell. Biol. (1996)
- CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells. Matsuda, M., Hashimoto, Y., Muroya, K., Hasegawa, H., Kurata, T., Tanaka, S., Nakamura, S., Hattori, S. Mol. Cell. Biol. (1994)
- Differential requirements for ERK1/2 and P38 MAPK activation by thrombin in T cells. Role of P59Fyn and PKCepsilon. Maulon, L., Mari, B., Bertolotto, C., Ricci, J.E., Luciano, F., Belhacene, N., Deckert, M., Baier, G., Auberger, P. Oncogene (2001)
- MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1. Ding, X.Z., Adrian, T.E. Biochem. Biophys. Res. Commun. (2001)
- Wavelength-specific activation of MAP kinase family proteins by monochromatic UV irradiation. Kabuyama, Y., Homma, M.K., Sekimata, M., Homma, Y. Photochem. Photobiol. (2001)
- Gefitinib and chemotherapy combination studies in five novel human non small cell lung cancer xenografts. Evidence linking EGFR signaling to gefitinib antitumor response. Judde, J.G., Rebucci, M., Vogt, N., de Cremoux, P., Livartowski, A., Chapelier, A., Tran-Perennou, C., Boye, K., Defrance, R., Poupon, M.F., Bras-Gonçalves, R.A. Int. J. Cancer (2007)
- Nitric oxide stimulates COX-2 expression in cultured collecting duct cells through MAP kinases and superoxide but not cGMP. Yang, T., Zhang, A., Pasumarthy, A., Zhang, L., Warnock, Z., Schnermann, J.B. Am. J. Physiol. Renal Physiol. (2006)
- Regulation of urokinase plasminogen activator by epigallocatechin-3-gallate in human fibrosarcoma cells. Kim, M.H., Jung, M.A., Hwang, Y.S., Jeong, M., Kim, S.M., Ahn, S.J., Shin, B.A., Ahn, B.W., Jung, Y.D. Eur. J. Pharmacol. (2004)
- Mitogen-Activated Protein Kinases Inhibit the ROMK (Kir 1.1)-Like Small Conductance K Channels in the Cortical Collecting Duct. Babilonia, E., Li, D., Wang, Z., Sun, P., Lin, D.H., Jin, Y., Wang, W.H. J. Am. Soc. Nephrol. (2006)
- Paxillin interactions. Turner, C.E. J. Cell. Sci. (2000)
- Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model. Fryknäs, M., Rickardson, L., Wickström, M., Dhar, S., Lövborg, H., Gullbo, J., Nygren, P., Gustafsson, M.G., Isaksson, A., Larsson, R. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. (2006)
- Mixed lineage kinase 3 inhibits phorbol myristoyl acetate-induced DNA synthesis but not osteopontin expression in rat mesangial cells. Parameswaran, N., Hall, C.S., Bock, B.C., Sparks, H.V., Gallo, K.A., Spielman, W.S. Mol. Cell. Biochem. (2002)
- Expression of erbB/HER receptors, heregulin and P38 in primary breast cancer using quantitative immunohistochemistry. Esteva, F.J., Hortobagyi, G.N., Sahin, A.A., Smith, T.L., Chin, D.M., Liang, S.Y., Pusztai, L., Buzdar, A.U., Bacus, S.S. Pathol. Oncol. Res. (2001)
- Fine mapping of an apparently targeted latent human herpesvirus type 6 integration site in chromosome band 17p13.3. Morris, C., Luppi, M., McDonald, M., Barozzi, P., Torelli, G. J. Med. Virol. (1999)