The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

Crk  -  CG1587 gene product from transcript CG1587-RD

Drosophila melanogaster

Synonyms: Adapter molecule Crk, CG1587, CRK, D-CRK, D-Crk, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Crk

  • The vertebrate adapter protein termed Crk was initially identified from the chicken CT10 retrovirus on the basis of its transforming activity (Mayer et al., 1988. Nature 332, 272-275) [1].
 

High impact information on Crk

  • MBC bears striking homology to human DOCK180, which interacts with the SH2-SH3 adapter protein Crk and may play a role in signal transduction from focal adhesions [2].
  • These sites are not required for MBC to rescue the muscle loss-of-function phenotype, however, which suggests that MBC's role in myoblast fusion can be carried out independently of direct DCrk binding [3].
  • DOCK180 was originally identified as one of two major proteins bound to the Crk oncogene product and became an archetype of the CDM family of proteins, including Ced-5 of Caenorhabditis elegans and Mbc of Drosophila melanogaster [4].
  • We have identified a Drosophila protein with homology to vertebrate Crk, termed dCRK, by interaction with the protein encoded by the Drosophila myoblast city (mbc) gene [1].

References

  1. Identification of a Drosophila homologue to vertebrate Crk by interaction with MBC. Galletta, B.J., Niu, X.P., Erickson, M.R., Abmayr, S.M. Gene (1999) [Pubmed]
  2. Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization. Erickson, M.R., Galletta, B.J., Abmayr, S.M. J. Cell Biol. (1997) [Pubmed]
  3. The CDM Superfamily Protein MBC Directs Myoblast Fusion through a Mechanism That Requires Phosphatidylinositol 3,4,5-Triphosphate Binding but Is Independent of Direct Interaction with DCrk. Balagopalan, L., Chen, M.H., Geisbrecht, E.R., Abmayr, S.M. Mol. Cell. Biol. (2006) [Pubmed]
  4. Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3. Kobayashi, S., Shirai, T., Kiyokawa, E., Mochizuki, N., Matsuda, M., Fukui, Y. Biochem. J. (2001) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities