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Gene Review

ced-2  -  Protein CED-2

Caenorhabditis elegans

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High impact information on ced-2

  • We provide evidence that CED-2 and CED-10 function in engulfing rather than dying cells to control the phagocytosis of cell corpses, that CED-2 and CED-5 physically interact, and that ced-10 probably functions downstream of ced-2 and ced-5 [1].
  • The gene products of ced-2, ced-5, and ced-10 are thought to be part of a pathway that regulates the reorganization of the cytoskeleton during engulfment [2].
  • Previously, three genes were known to be involved in eliminating cell corpses in the nematode Caenorhabditis elegans: ced-1, ced-2 and nuc-1 [3].

Biological context of ced-2


Other interactions of ced-2

  • Here we find that ced-2 and ced-10 encode proteins similar to the human adaptor protein CrkII and the human GTPase Rac, respectively [1].


  1. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Reddien, P.W., Horvitz, H.R. Nat. Cell Biol. (2000) [Pubmed]
  2. Evidence for a conserved role for CRKII and Rac in engulfment of apoptotic cells. Tosello-Trampont, A.C., Brugnera, E., Ravichandran, K.S. J. Biol. Chem. (2001) [Pubmed]
  3. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Ellis, R.E., Jacobson, D.M., Horvitz, H.R. Genetics (1991) [Pubmed]
  4. Cell engulfment, no sooner ced than done. Conradt, B. Dev. Cell (2001) [Pubmed]
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