Gene Review:
Crk - v-crk avian sarcoma virus CT10 oncogene...
Rattus norvegicus
Synonyms:
Adapter molecule crk, Crko, Proto-oncogene c-Crk, p38
- Isoflurane preconditioning induces neuroprotection against ischemia via activation of P38 mitogen-activated protein kinases. Zheng, S., Zuo, Z. Mol. Pharmacol. (2004)
- P38 mitogen-activated protein kinase inhibition attenuates ischemia-reperfusion injury of the rat liver. Kobayashi, M., Takeyoshi, I., Yoshinari, D., Matsumoto, K., Morishita, Y. Surgery (2002)
- Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells. Sakaida, I., Hironaka, K., Terai, S., Okita, K. Life Sci. (2003)
- Alterations in geniculate ganglion proteins following fungiform receptor damage. Lasiter, P.S., Bulcourf, B.B. Brain Res. Dev. Brain Res. (1995)
- Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells. Shen, J., Sakaida, I., Uchida, K., Terai, S., Okita, K. Life Sci. (2005)
- Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. Minegishi, M., Tachibana, K., Sato, T., Iwata, S., Nojima, Y., Morimoto, C. J. Exp. Med. (1996)
- Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells. Hellemans, K., Michalik, L., Dittie, A., Knorr, A., Rombouts, K., De Jong, J., Heirman, C., Quartier, E., Schuit, F., Wahli, W., Geerts, A. Gastroenterology (2003)
- Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. Abassi, Y.A., Vuori, K. EMBO J. (2002)
- Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells. Petit, V., Boyer, B., Lentz, D., Turner, C.E., Thiery, J.P., Vallés, A.M. J. Cell Biol. (2000)
- Crk associates with ERM proteins and promotes cell motility toward hyaluronic acid. Tsuda, M., Makino, Y., Iwahara, T., Nishihara, H., Sawa, H., Nagashima, K., Hanafusa, H., Tanaka, S. J. Biol. Chem. (2004)
- Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells. Ribon, V., Saltiel, A.R. J. Biol. Chem. (1996)
- Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. Escalante, M., Courtney, J., Chin, W.G., Teng, K.K., Kim, J.I., Fajardo, J.E., Mayer, B.J., Hempstead, B.L., Birge, R.B. J. Biol. Chem. (2000)
- c-SRC mediates neurite outgrowth through recruitment of Crk to the scaffolding protein Sin/Efs without altering the kinetics of ERK activation. Yang, L.T., Alexandropoulos, K., Sap, J. J. Biol. Chem. (2002)
- Networks of interaction of p120cbl and p130cas with Crk and Grb2 adaptor proteins. Khwaja, A., Hallberg, B., Warne, P.H., Downward, J. Oncogene (1996)
- Signaling adaptor protein v-Crk activates Rho and regulates cell motility in 3Y1 rat fibroblast cell line. Tsuda, M., Tanaka, S., Sawa, H., Hanafusa, H., Nagashima, K. Cell Growth Differ. (2002)
- Glucose stimulates the association of Crk with p130Cas in pancreatic beta cells. Lee, T.N., Gold, G., Workman, R., Cook, C.A., Konrad, R.J. Pancreas (2004)
- Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways. Feller, S.M., Knudsen, B., Hanafusa, H. Oncogene (1995)
- Ruk is ubiquitinated but not degraded by the proteasome. Verdier, F., Valovka, T., Zhyvoloup, A., Drobot, L.B., Buchman, V., Waterfield, M., Gout, I. Eur. J. Biochem. (2002)
- Temporal dissection of beta1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation. Gustavsson, A., Yuan, M., Fällman, M. J. Biol. Chem. (2004)
- Depolarization-induced tyrosine phosphorylation of paxillin in PC12h cells. Khan, M.A., Okumura, N., Okada, M. Eur. J. Biochem. (1996)
- Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation. Kodama, H., Fukuda, K., Takahashi, E., Tahara, S., Tomita, Y., Ieda, M., Kimura, K., Owada, K.M., Vuori, K., Ogawa, S. Hypertension (2003)
- Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules. Nakamura, T., Komiya, M., Gotoh, N., Koizumi, S., Shibuya, M., Mori, N. Oncogene (2002)
- c-Src association with and phosphorylation of p58gag, a membrane- and microfilament-associated retroviral Gag-like protein in a xenotransplantable rat mammary tumor. Huang, J., Zhang, B.T., Li, Y., Mayer, B., Carraway, K.L., Carraway, C.A. Oncogene (1999)
- Optimal conditions for long-term photoreceptor cell rescue in RCS rats: the necessity for healthy RPE transplants. Li, L., Turner, J.E. Exp. Eye Res. (1991)
- P38 mitogen-activated protein kinase inhibition attenuates pulmonary inflammatory response in a rat cardiopulmonary bypass model. Dong, X., Liu, Y., Du, M., Wang, Q., Yu, C.T., Fan, X. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2006)
- Effects of extracellular matrix on phenotype modulation and MAPK transduction of rat aortic smooth muscle cells in vitro. Qin, H., Ishiwata, T., Wang, R., Kudo, M., Yokoyama, M., Naito, Z., Asano, G. Exp. Mol. Pathol. (2000)
- Attenuation of ischemia/reperfusion induced MAP kinases by N-acetyl cysteine, sodium nitroprusside and phosphoramidon. Mehta, A., Sekhon, C.P., Giri, S., Orak, J.K., Singh, A.K. Mol. Cell. Biochem. (2002)