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Gene Review:

MUC1 - mucin 1, cell surface associated

Canis lupus familiaris

Pemberton, L.F. et al.

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High impact information on MUC1

The MUC1 gene product (PEM, polymorphic epithelial mucin) is a cell-associated glycoprotein expressed on the apical surface of most simple secretory epithelia [1].
The transmembrane and cytoplasmic domains of MUC1 have been shown to be highly conserved between mammalian species, and it has been shown that this molecule interacts with the actin cytoskeleton [1].

Analytical, diagnostic and therapeutic context of MUC1

Using cytoplasmic tail deletion mutants, fusion proteins of MUC1 and CD2, and site-directed mutagenesis, it could be shown that MUC1 appeared to contain at least two motifs involved in apical localization [1].

References

The epithelial mucin MUC1 contains at least two discrete signals specifying membrane localization in cells. Pemberton, L.F., Rughetti, A., Taylor-Papadimitriou, J., Gendler, S.J. J. Biol. Chem. (1996) [Pubmed]

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