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Gene Review: 

eIF-3p40  -  Eukaryotic initiation factor 3 p40 subunit

Drosophila melanogaster

Synonyms: BcDNA:GM14618, CG9124, Dmel\CG9124, Dmel_CG9124, Eukaryotic translation initiation factor 3 subunit 3, ...
 
 
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High impact information on eIF-3p40

  • The mammalian translation initiation factor 3 (eIF3), is a multiprotein complex of approximately 600 kDa that binds to the 40 S ribosome and promotes the binding of methionyl-tRNAi and mRNA. cDNAs encoding 5 of the 10 subunits, namely eIF3-p170, -p116, -p110, -p48, and -p36, have been isolated previously [1].
  • The 1.5kb eIF-3p48/INT-6 RNA species encodes a protein composed of 364 amino-acid residues whose sequence is 71% similar to that of the mouse/human eIF-3/INT-6 amino-acid sequence. eIF-3p48/INT-6 RNA is expressed throughout development in Drosophila and the encoded protein is associated with the microsomal subcellular fraction [2].
  • Sequences homologous with eIF3k are found in the genomes of Caenorhabitis elegans, Arabidopsis thaliana and Drosophila melanogaster, and a homologous protein has been reported to be present in wheat eIF3 [3].

References

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. Asano, K., Vornlocher, H.P., Richter-Cook, N.J., Merrick, W.C., Hinnebusch, A.G., Hershey, J.W. J. Biol. Chem. (1997) [Pubmed]
  2. Characterization of the Drosophila ortholog of mouse eIF-3p48/INT-6. Miyazaki, S., Rasmussen, S., Imatani, A., Diella, F., Sullivan, D.T., Callahan, R. Gene (1999) [Pubmed]
  3. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3. Mayeur, G.L., Fraser, C.S., Peiretti, F., Block, K.L., Hershey, J.W. Eur. J. Biochem. (2003) [Pubmed]
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