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Gene Review

MYO1C  -  myosin IC

Homo sapiens

Synonyms: MMI-beta, MMIb, Myosin I beta, NMI, Unconventional myosin-Ic, ...
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High impact information on MYO1C

  • A second widely distributed myosin I molecule similar to myr 1 and brush border myosin I, called myr 2, has now been identified [1].
  • In subcellular fractionation experiments myr 1 and myr 2 were both partly soluble and partly associated with smooth membranes of medium density [1].
  • The screen identified interactions involving c-Cbl and two 14-3-3 isoforms, cytokeratin 18, human unconventional myosin IC, and a recently identified SH3 domain containing protein, SH3 P17 [2].


  1. Localization of the rat myosin I molecules myr 1 and myr 2 and in vivo targeting of their tail domains. Ruppert, C., Godel, J., Müller, R.T., Kroschewski, R., Reinhard, J., Bähler, M. J. Cell. Sci. (1995) [Pubmed]
  2. A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components. Robertson, H., Langdon, W.Y., Thien, C.B., Bowtell, D.D. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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