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Gene Review

Myo1c  -  myosin IC

Mus musculus

Synonyms: C80397, MMI-beta, MMIb, MYO1E, Myosin I beta, ...
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High impact information on Myo1c

  • Myosin-1c (also known as myosin-Ibeta) has been proposed to mediate the slow component of adaptation by hair cells, the sensory cells of the inner ear [1].
  • Insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane is augmented by the expression of wild-type Myo1c and inhibited by a dominant-negative cargo domain of Myo1c [2].
  • Insulin enhances the localization of Myo1c with GLUT4 in cortical tubulovesicular structures associated with actin filaments, and this colocalization is insensitive to wortmannin [2].
  • A decrease in the expression of endogenous Myo1c mediated by small interfering RNAs inhibits insulin-stimulated uptake of 2-deoxyglucose [2].
  • In contrast, dominant inhibitory Myo1c cargo domain expression diminished this interaction and inhibited IRS-1 phosphorylation [3].

Biological context of Myo1c


Anatomical context of Myo1c

  • Myo1c, which contains a motor domain, three IQ motifs and a carboxy-terminal cargo domain, is highly expressed in primary and cultured adipocytes [2].
  • The first cDNA encodes a putative protein named Myo1c, which is likely to be the murine orthologue of the bullfrog myosin I beta and which may be involved in the gating of the mechanotransduction channel of the sensory hair cells [7].
  • In these studies, we investigated the function of the unconventional myosin I Myo1c in the M1 mouse collecting duct cell line [8].
  • Recent data indicate that Myo1c interacts in vitro with two other molecules proposed to be important for transduction: cadherin 23 (Cdh23), a candidate for the stereociliary tip link, and phosphatidylinositol 4,5-bisphosphate (PIP2), which is abundant in the membranes of hair-cell stereocilia [9].
  • Binding of Myo1c to stereociliary tips of cochlear and vestibular hair cells is disrupted by treatments that break tip links [9].

Associations of Myo1c with chemical compounds


Other interactions of Myo1c


Analytical, diagnostic and therapeutic context of Myo1c

  • Northern blot analysis indicated that the genes encoding Myo1c and Myo1f display a widespread tissue expression in the adult mouse [7].


  1. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Holt, J.R., Gillespie, S.K., Provance, D.W., Shah, K., Shokat, K.M., Corey, D.P., Mercer, J.A., Gillespie, P.G. Cell (2002) [Pubmed]
  2. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Bose, A., Guilherme, A., Robida, S.I., Nicoloro, S.M., Zhou, Q.L., Jiang, Z.Y., Pomerleau, D.P., Czech, M.P. Nature (2002) [Pubmed]
  3. Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1. Nakamori, Y., Emoto, M., Fukuda, N., Taguchi, A., Okuya, S., Tajiri, M., Miyagishi, M., Taira, K., Wada, Y., Tanizawa, Y. J. Cell Biol. (2006) [Pubmed]
  4. Chromosomal location of three unconventional myosin heavy chain genes in the mouse. Whitmer, J.D., Koslovsky, J.S., Bähler, M., Mercer, J.A. Genomics (1996) [Pubmed]
  5. Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway. Bose, A., Robida, S., Furcinitti, P.S., Chawla, A., Fogarty, K., Corvera, S., Czech, M.P. Mol. Cell. Biol. (2004) [Pubmed]
  6. Dynamics of cytoskeletal proteins during Fcgamma receptor-mediated phagocytosis in macrophages. Diakonova, M., Bokoch, G., Swanson, J.A. Mol. Biol. Cell (2002) [Pubmed]
  7. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Crozet, F., el Amraoui, A., Blanchard, S., Lenoir, M., Ripoll, C., Vago, P., Hamel, C., Fizames, C., Levi-Acobas, F., Depétris, D., Mattei, M.G., Weil, D., Pujol, R., Petit, C. Genomics (1997) [Pubmed]
  8. Expression of the unconventional myosin Myo1c alters sodium transport in M1 collecting duct cells. Wagner, M.C., Blazer-Yost, B.L., Boyd-White, J., Srirangam, A., Pennington, J., Bennett, S. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  9. Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice. Phillips, K.R., Tong, S., Goodyear, R., Richardson, G.P., Cyr, J.L. J. Neurosci. (2006) [Pubmed]
  10. Myo1c binds tightly and specifically to phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate. Hokanson, D.E., Ostap, E.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  11. Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes. Huang, J., Imamura, T., Babendure, J.L., Lu, J.C., Olefsky, J.M. J. Biol. Chem. (2005) [Pubmed]
  12. Unconventional myosins in inner-ear sensory epithelia. Hasson, T., Gillespie, P.G., Garcia, J.A., MacDonald, R.B., Zhao, Y., Yee, A.G., Mooseker, M.S., Corey, D.P. J. Cell Biol. (1997) [Pubmed]
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