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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NDUFA4  -  NDUFA4, mitochondrial complex associated

Homo sapiens

Synonyms: CI-9k, CI-MLRQ, Complex I-MLRQ, Cytochrome c oxidase subunit NDUFA4, MLRQ, ...
 
 
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High impact information on NDUFA4

  • This revealed that three nDNA complex I genes (NDUFC2, NDUFA1, and NDUFA4) had significantly increased amino acid substitution rates by both PAML and Z-test, suggesting that they have been subjected to adaptive selection during primate radiation [1].
  • In particular, almost all nuclear (except MLRQ) and 5 mitochondria DNA encoded subunits (except ND4L and ND6) were identified [2].
  • Some OXPHOS subunits (cytochrome c, subunit c of ATP synthase and MLRQ) are encoded by several nuclear duplicated genes which still represent the trace of an ancient segmental/genome duplication event at the origin of vertebrates [3].
  • The deduced amino acid sequence exhibited 95% homology (88% identity and 7% favored substitution) to that of bovine MLRQ subunit [4].
  • A cDNA clone encoding human NADH:ubiquinone oxidoreductase (complex I of mitochondrial respiratory chain) MLRQ subunit was isolated from human fetal liver cDNA library [4].

References

  1. Adaptive selection of mitochondrial complex I subunits during primate radiation. Mishmar, D., Ruiz-Pesini, E., Mondragon-Palomino, M., Procaccio, V., Gaut, B., Wallace, D.C. Gene (2006) [Pubmed]
  2. Shotgun proteomics for the characterization of subunit composition of mitochondrial complex I. Pocsfalvi, G., Cuccurullo, M., Schlosser, G., Cacace, G., Siciliano, R.A., Mazzeo, M.F., Scacco, S., Cocco, T., Gnoni, A., Malorni, A., Papa, S. Biochim. Biophys. Acta (2006) [Pubmed]
  3. Metazoan OXPHOS gene families: Evolutionary forces at the level of mitochondrial and nuclear genomes. Saccone, C., Lanave, C., De Grassi, A. Biochim. Biophys. Acta (2006) [Pubmed]
  4. Cloning of the human cDNA sequence encoding the NADH:ubiquinone oxidoreductase MLRQ subunit. Kim, J.W., Lee, Y., Kang, H.B., Chose, Y.K., Chung, T.W., Chang, S.Y., Lee, K.S., Choe, I.S. Biochem. Mol. Biol. Int. (1997) [Pubmed]
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