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Gene Review

NDUFA9  -  NADH dehydrogenase (ubiquinone) 1 alpha...

Homo sapiens

Synonyms: CC6, CI-39k, CI-39kD, CI39k, Complex I-39kD, ...
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High impact information on NDUFA9

  • Western blot analysis revealed a decrease of the 20 kDa subunit (likely ND6) and of the 30 kDa subunit (NDUFA9), which is probably due to instability attributed to the inability to form subcomplexes with ND3 [1].
  • To study the ability of mitochondrial biogenesis in human granulosa cells, we determined the mitochondrial marker proteins, including the nuclear-encoded NADH-ubiquinone oxidoreductase alpha subunit 9 (NDUFA9) and mitochondrial-encoded COX I, after treatment of the cells with the calcium ionophore A23187 [2].


  1. Fulminant neurological deterioration in a neonate with Leigh syndrome due to a maternally transmitted missense mutation in the mitochondrial ND3 gene. Leshinsky-Silver, E., Lev, D., Tzofi-Berman, Z., Cohen, S., Saada, A., Yanoov-Sharav, M., Gilad, E., Lerman-Sagie, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. Calcium stimulates mitochondrial biogenesis in human granulosa cells. Yeh, T.S., Ho, J.D., Yang, V.W., Tzeng, C.R., Hsieh, R.H. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
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