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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NF1P3  -  neurofibromin 1 pseudogene 3

Homo sapiens

 
 
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High impact information on NF1L1

  • To determine how these mutations interfere with factor IX expression, we have assayed for transcription factors binding to this area and have identified a nuclear factor-1 liver (NF1-L) binding site (-99 to -76) and a binding site for the CCAAT/enhancer binding protein (C/EBP) (+1 to +18) [1].
  • The NF1-L site on the rPARP promoter overlaps one of the Sp1 binding sites previously identified, and we demonstrated that binding of both factors to this composite element is mutually exclusive [2].
  • Results from both gel mobility supershift assays and Western-blot analyses, performed in combination with a polyclonal antibody directed against the DNA-binding domain of NF1-L, indicated that rat liver nuclear factor 1 might indeed correspond to one of the transcription factors interacting with the rat growth-hormone proximal silencer element [3].
  • The amino acid sequences of three fragments were identical to those of rat NF1-L, and that of the other fragment was the same as that of hamster NF1/Red1 [4].

References

  1. Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B. Crossley, M., Brownlee, G.G. Nature (1990) [Pubmed]
  2. Nuclear factor 1 interferes with Sp1 binding through a composite element on the rat poly(ADP-ribose) polymerase promoter to modulate its activity in vitro. Laniel, M.A., Poirier, G.G., Guerin, S.L. J. Biol. Chem. (2001) [Pubmed]
  3. The 30-kDa rat liver transcription factor nuclear factor 1 binds the rat growth-hormone proximal silencer. Roy, R.J., Guérin, S.L. Eur. J. Biochem. (1994) [Pubmed]
  4. Nuclear factor 1 family proteins bind to the silencer element in the rat glutathione transferase P gene. Osada, S., Daimon, S., Ikeda, T., Nishihara, T., Yano, K., Yamasaki, M., Imagawa, M. J. Biochem. (1997) [Pubmed]
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