High impact information on Eip63F-1

• The Drosophila 63F early puff contains E63-1, an ecdysone-inducible gene that encodes a novel Ca(2+)-binding protein [1].
• Second, E63-1 induction in late third instar larvae appears to be highly tissue-specific, restricted to the salivary gland [1].
• Third, E63-1 encodes a novel Ca(2+)-binding protein related to calmodulin [1].
• We show that 20E mediates secretion through the EcR/USP receptor, and two early-gene products, the rbp(+) function of BR-C and the Ca2+ binding protein E63-1, are involved [2].
• Genetic analysis of the Drosophila 63F early puff. Characterization of mutations in E63-1 and maggie, a putative Tom22 [3].

Biological context of Eip63F-1

• E63-1 encodes a member of the EF-hand family of Ca(2+)-binding proteins, while E63-2 has no apparent open reading frame [3].
• The 63F early puff in the larval salivary gland polytene chromosomes contains the divergently transcribed E63-1 and E63-2 ecdysone-inducible genes [3].

Anatomical context of Eip63F-1

• Furthermore, the subcellular distribution of E63-1 protein changes dynamically in the salivary glands at the onset of metamorphosis [3].

References