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Gene Review:

NIDDM2 - non-insulin-dependent diabetes mellitus...

Homo sapiens

Winckler, W. et al., Chen, Y.D. et al., Nosadini, R. et al., Urhammer, S.A. et al., Bektas, A. et al.

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Disease relevance of NIDDM2

Diabetic patients were divided into four subgroups: those with normoalbuminuria without (NIDDM1) and with (NIDDM2) hypertension and those with microalbuminuria without (NIDDM3) and with (NIDDM4) hypertension [1].

High impact information on NIDDM2

The gene for MODY3 diabetes, HNF1alpha, lies in a region that has shown linkage to late-onset type 2 diabetes (12q24, NIDDM2), and previous association studies have suggested a weak trend toward association for common missense variants in HNF1alpha with glucose-related traits [2].
Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q [3].
Since it has been the convention to use the nonsteady state equations of Steele to calculate HGP in patients with NIDDM 2 h after [3-3H] glucose administration, it is almost certain that published values for HGP in patients with NIDDM are falsely high [4].

Other interactions of NIDDM2

These findings suggest that NIDDM2 and MODY3 may represent different alleles of the same gene [5].

References

Close relationship between microalbuminuria and insulin resistance in essential hypertension and non-insulin dependent diabetes mellitus. Nosadini, R., Cipollina, M.R., Solini, A., Sambataro, M., Morocutti, A., Doria, A., Fioretto, P., Brocco, E., Muollo, B., Frigato, F. J. Am. Soc. Nephrol. (1992) [Pubmed]
Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes. Winckler, W., Burtt, N.P., Holmkvist, J., Cervin, C., de Bakker, P.I., Sun, M., Almgren, P., Tuomi, T., Gaudet, D., Hudson, T.J., Ardlie, K.G., Daly, M.J., Hirschhorn, J.N., Altshuler, D., Groop, L. Diabetes (2005) [Pubmed]
Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q. Bektas, A., Suprenant, M.E., Wogan, L.T., Plengvidhya, N., Rich, S.S., Warram, J.H., Krolewski, A.S., Doria, A. Diabetes (1999) [Pubmed]
Effect of time on measurement of hepatic glucose production. Chen, Y.D., Swislocki, A.L., Jeng, C.Y., Juang, J.H., Reaven, G.M. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDM. Urhammer, S.A., Rasmussen, S.K., Kaisaki, P.J., Oda, N., Yamagata, K., Møller, A.M., Fridberg, M., Hansen, L., Hansen, T., Bell, G.I., Pedersen, O. Diabetologia (1997) [Pubmed]

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