Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Hsp60B - Heat shock protein 60 related

Drosophila melanogaster

Synonyms: 152031_at, 60 kDa chaperonin, 60 kDa heat shock protein homolog 1, mitochondrial, CG2830, CPN60, ...

Timakov, B. et al., Sarkar, S. et al.

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High impact information on Hsp60B

Our observation that the hsp60B mutation displayed no apparent defect in mitochondrial differentiation during spermatogenesis suggests that the Hsp60B protein may operate in a nonmitochondrial location [1].
The hsp60B gene of Drosophila melanogaster is essential for the spermatid individualization process [1].
In males homozygous for a mutation of the hsp60B gene, developmental processes appeared normal throughout most of spermatogenesis, including spermatocyte growth, meiosis, and spermatid elongation [1].
The absence of early meiotic stages in the Hsp60C(1) homozygous testes contrasts with the effect of testis-specific Hsp60B (21D) gene, whose mutation affects individualization of sperm bundles later in spermiogenesis [2].

References

The hsp60B gene of Drosophila melanogaster is essential for the spermatid individualization process. Timakov, B., Zhang, P. Cell Stress Chaperones (2001) [Pubmed]
The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility. Sarkar, S., Lakhotia, S.C. J. Genet. (2005) [Pubmed]

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