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Gene Review

NPAS1  -  neuronal PAS domain protein 1

Homo sapiens

Synonyms: BHLHE11, Basic-helix-loop-helix-PAS protein MOP5, Class E basic helix-loop-helix protein 11, MOP5, Member of PAS protein 5, ...
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Disease relevance of NPAS1


High impact information on NPAS1


Biological context of NPAS1

  • In the absence of ARNT, NPAS1 is excluded from the nucleus, and this exclusion is due to the presence of a nuclear export signal within the N terminus of NPAS1 [3].
  • MOP5 contained the characteristic PAS domain and a variable C terminus; it is possible that the cDNA contains a bHLH domain, but the entire open reading frame has yet to be completed [4].

Other interactions of NPAS1

  • We showed that the nuclear localization of NPAS1 is dependent on the presence of ARNT [3].

Analytical, diagnostic and therapeutic context of NPAS1

  • In situ hybridization assays using brain tissue of postnatal mice revealed an exclusively neuronal pattern of expression for NPAS1 and NPAS2 mRNAs [2].
  • In this population-based case control study (n = 455 cases; 527 controls), we examined the only identified nonsynonymous polymorphism (Ala394Thr; rs2305160) in the largest circadian gene, neuronal PAS domain protein 2 (NPAS2), in order to examine its impact on NHL risk [1].
  • The rates of complications as well as the mean operation times and mean durations of hospitalization (indices of medical costs) did not differ significantly between the PAS and NPAS groups [5].


  1. Ala394Thr polymorphism in the clock gene NPAS2: A circadian modifier for the risk of non-Hodgkin's lymphoma. Zhu, Y., Leaderer, D., Guss, C., Brown, H.N., Zhang, Y., Boyle, P., Stevens, R.G., Hoffman, A., Qin, Q., Han, X., Zheng, T. Int. J. Cancer (2007) [Pubmed]
  2. Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Zhou, Y.D., Barnard, M., Tian, H., Li, X., Ring, H.Z., Francke, U., Shelton, J., Richardson, J., Russell, D.W., McKnight, S.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Neuronal PAS Domain Protein 1 Is a Transcriptional Repressor and Requires Arylhydrocarbon Nuclear Translocator for Its Nuclear Localization. Teh, C.H., Lam, K.K., Loh, C.C., Loo, J.M., Yan, T., Lim, T.M. J. Biol. Chem. (2006) [Pubmed]
  4. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. Hogenesch, J.B., Chan, W.K., Jackiw, V.H., Brown, R.C., Gu, Y.Z., Pray-Grant, M., Perdew, G.H., Bradfield, C.A. J. Biol. Chem. (1997) [Pubmed]
  5. Previous abdominal surgery as a risk factor in interval laparoscopic sterilization. Chi, I., Feldblum, P.J., Balogh, S.A. Am. J. Obstet. Gynecol. (1983) [Pubmed]
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