Disease relevance of NPAS1

• Ala394Thr polymorphism in the clock gene NPAS2: A circadian modifier for the risk of non-Hodgkin's lymphoma [1].

High impact information on NPAS1

• RNA blotting assays demonstrated the selective presence of NPAS1 and NPAS2 mRNAs in brain and spinal cord tissues of adult mice [2].
• NPAS1 mRNA was first detected at embryonic day 15 of mouse development, shortly after early organogenesis of the brain [2].
• Furthermore, our experiments showed that NPAS1 is able to repress the transactivation functions of ARNT and ARNT2 [3].
• We found no transactivation domain within NPAS1; instead, we mapped out at least three repression domains within NPAS1, suggesting that NPAS1 acts as a repressor [3].
• Neuronal PAS domain protein 1 (NPAS1), a basic helix-loop-helix-PAS transcription factor expressed in the central nervous system, has been suggested to be involved in neuronal differentiation [3].

Biological context of NPAS1

• In the absence of ARNT, NPAS1 is excluded from the nucleus, and this exclusion is due to the presence of a nuclear export signal within the N terminus of NPAS1 [3].
• MOP5 contained the characteristic PAS domain and a variable C terminus; it is possible that the cDNA contains a bHLH domain, but the entire open reading frame has yet to be completed [4].

Other interactions of NPAS1

• We showed that the nuclear localization of NPAS1 is dependent on the presence of ARNT [3].

Analytical, diagnostic and therapeutic context of NPAS1

• In situ hybridization assays using brain tissue of postnatal mice revealed an exclusively neuronal pattern of expression for NPAS1 and NPAS2 mRNAs [2].
• In this population-based case control study (n = 455 cases; 527 controls), we examined the only identified nonsynonymous polymorphism (Ala394Thr; rs2305160) in the largest circadian gene, neuronal PAS domain protein 2 (NPAS2), in order to examine its impact on NHL risk [1].
• The rates of complications as well as the mean operation times and mean durations of hospitalization (indices of medical costs) did not differ significantly between the PAS and NPAS groups [5].

References