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STS  -  steroid sulfatase (microsomal), isozyme S

Canis lupus familiaris

 
 
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Disease relevance of STS

  • Thomas hospital solution (STS) during ischemia; group 2: warm blood cardioplegia enriched with amino acid (L-asparte and L-glutamate 13 mmol/L each) and STS without amino acid (A. G.) and group 3: both warm blood cardioplegic solution and STS enriched with A [1].
 

High impact information on STS

  • Samples from two mucous membrane sites (anterior nares and mouth), and two hair-coated sites (head and withers) were taken from 122 dogs and inoculated into STS agar, a novel selective medium that was introduced and tested in the study [2].
  • Each STS delivered approximately 5 mg selegiline over 24 h [3].
  • The toxicology and toxicokinetics of a selegiline transdermal system (STS) were evaluated in a 3 month dog study of daily 24 h applications of placebo 4, 8, or 12 STSs in 32 male and 32 female beagle dogs [3].

References

  1. Effect of amino acid cardioplegia on myocardial metabolism and function of ischemic canine heart. Zhang, K., Lan, H., Cheng, G., Fu, P., Huang, Y., Xu, Z., Feng, H. J. Tongji Med. Univ. (1997) [Pubmed]
  2. Staphylococcus sciuri as a part of skin, nasal and oral flora in healthy dogs. Stepanović, S., Dimitrijević, V., Vuković, D., Dakić, I., Savić, B., Svabic-Vlahović, M. Vet. Microbiol. (2001) [Pubmed]
  3. Toxicokinetic evaluation of a selegiline transdermal system in the dog. Barrett, J.S., DiSanto, A.R., Thomford, P.J., Larsen, E.M., Palazzolo, M.J., Morales, R.J. Biopharmaceutics & drug disposition. (1997) [Pubmed]
 
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