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Gene Review:

PRNP - prion protein

Felis catus

Velayos, J.L. et al., Willoughby, K. et al., Kelly, D.F. et al., Morita, T. et al., Lysek, D.A. et al.

Velayos, Oliva, Alfageme, Lysek, Nivon, Wüthrich,

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Disease relevance of PRNP

Based on the connectivity and histochemistry findings, the possibility that prion agents responsible for fatal familial insomnia spread from the mediodorsal and anterior thalamic nuclei through a retrograde pathway is discussed [1].

High impact information on PRNP

Amino acid sequence of the Felis catus prion protein [2].
Immunohistochemically, abnormal accumulation of prion protein (PrP) was not detected in the brain stem lesions [3].
Immunostaining with a polyclonal antiserum revealed prion protein (PrP) associated with these changes in sections of cervical spinal cord and medulla [4].

Analytical, diagnostic and therapeutic context of PRNP

Disease-specific prion protein (PrP(Sc)) was observed in only one of the 173 cats examined by immunohistochemistry [5].

References

Afferent projections to the mediodorsal and anterior thalamic nuclei in the cat. Anatomical-clinical correlations. Velayos, J.L., Oliva, M., Alfageme, F. Brain Pathol. (1998) [Pubmed]
Amino acid sequence of the Felis catus prion protein. Lysek, D.A., Nivon, L.G., Wüthrich, K. Gene (2004) [Pubmed]
Congenital spongiform change in the brain stem nuclei of a domestic kitten. Morita, T., Shimada, A., Ishibashi, T., Kimura, K., Haritani, M., Umemura, T. J. Comp. Pathol. (2002) [Pubmed]
Spongiform encephalopathy in a captive puma (Felis concolor). Willoughby, K., Kelly, D.F., Lyon, D.G., Wells, G.A. Vet. Rec. (1992) [Pubmed]
Neuropathological findings in cats with clinically suspect but histologically unconfirmed feline spongiform encephalopathy. Kelly, D.F., Wells, G.A., Haritani, M., Higgins, R.J., Jeffrey, M. Vet. Rec. (2005) [Pubmed]

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