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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Brain Stem

 
 
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Disease relevance of Brain Stem

  • The brain-stem conduction time of the auditory evoked response (Wave V-I interval) was longer in babies with apnea than in those without it at a similar postconceptional age (at 32 to 33 weeks: mean, 6.16 vs. 5.35 msec, P less than 0.001; at 34 to 35 weeks: mean, 5.98 vs. 5.33 msec, P less than 0.002) [1].
  • However, only the brain stem activation persisted after the injection of sumatriptan had induced complete relief from headache and phono- and photophobia [2].
  • Neurological accompaniments, subacute and usually multifocal, included sensory/sensorimotor neuropathies, cerebellar ataxia, myelopathy, brain stem and limbic encephalopathy [3].
  • Four patients were followed over several days from a state of coma with evidence of preserved brain-stem and cerebral functions to a clinical state compatible with brain death [4].
  • The other neuroblastomas expressed B120 gene product in the nucleus; however, the intensity of staining was much weaker and equivalent to that in developing human brain stem cells in the subventricular region [5].
 

Psychiatry related information on Brain Stem

 

High impact information on Brain Stem

 

Chemical compound and disease context of Brain Stem

 

Biological context of Brain Stem

 

Anatomical context of Brain Stem

 

Associations of Brain Stem with chemical compounds

 

Gene context of Brain Stem

  • The expression of Nhlh1 in the developing brain stem and in the vagal nuclei in the wild-type mouse further supports this hypothesis [34].
  • In contrast, antisera to NPY and APP labeled local neurons systems in the spinal dorsal horn, in the lateral parts of the brain stem, including the rhombencephalic alar plate, and in the retina [35].
  • Multiple forms of pancreatic polypeptide-related compounds in the lamprey CNS: partial characterization and immunohistochemical localization in the brain stem and spinal cord [35].
  • Selenium-dependent GSH-Px activity did not significantly change in 12-month-old rats but it increased in the lower brain stem of 24-month-old animals [36].
  • PURPOSE: This study was conducted to investigate the incidence of ERBB1 amplification and overexpression in samples of diffusely infiltrative (WHO grades II-IV) pediatric brain stem glioma (BSG) and determine the relationship of these abnormalities to expression and mutation of TP53 and tumor grade [37].
 

Analytical, diagnostic and therapeutic context of Brain Stem

References

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  21. Congenital abnormalities in Brazilian children associated with misoprostol misuse in first trimester of pregnancy. Gonzalez, C.H., Marques-Dias, M.J., Kim, C.A., Sugayama, S.M., Da Paz, J.A., Huson, S.M., Holmes, L.B. Lancet (1998) [Pubmed]
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  23. Neuronal nitric oxide reduces sympathetic excitability by modulation of central glutamate effects in pigs. Zanzinger, J., Czachurski, J., Seller, H. Circ. Res. (1997) [Pubmed]
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  25. The renin-angiotensin system in the central control of blood pressure. Rettig, R., Ganten, D., Lang, R.E., Unger, T. Eur. Heart J. (1987) [Pubmed]
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  29. Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases. Iacopino, A.M., Christakos, S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
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  32. Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. Robichaud, A., Stamatiou, P.B., Jin, S.L., Lachance, N., MacDonald, D., Laliberté, F., Liu, S., Huang, Z., Conti, M., Chan, C.C. J. Clin. Invest. (2002) [Pubmed]
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  34. Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice. Cogliati, T., Good, D.J., Haigney, M., Delgado-Romero, P., Eckhaus, M.A., Koch, W.J., Kirsch, I.R. Mol. Cell. Biol. (2002) [Pubmed]
  35. Multiple forms of pancreatic polypeptide-related compounds in the lamprey CNS: partial characterization and immunohistochemical localization in the brain stem and spinal cord. Brodin, L., Rawitch, A., Taylor, T., Ohta, Y., Ring, H., Hökfelt, T., Grillner, S., Terenius, L. J. Neurosci. (1989) [Pubmed]
  36. NGF restores decrease in catalase activity and increases superoxide dismutase and glutathione peroxidase activity in the brain of aged rats. Nisticò, G., Ciriolo, M.R., Fiskin, K., Iannone, M., De Martino, A., Rotilio, G. Free Radic. Biol. Med. (1992) [Pubmed]
  37. ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. Gilbertson, R.J., Hill, D.A., Hernan, R., Kocak, M., Geyer, R., Olson, J., Gajjar, A., Rush, L., Hamilton, R.L., Finkelstein, S.D., Pollack, I.F. Clin. Cancer Res. (2003) [Pubmed]
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