Disease relevance of Anterior Thalamic Nuclei

• Based on the connectivity and histochemistry findings, the possibility that prion agents responsible for fatal familial insomnia spread from the mediodorsal and anterior thalamic nuclei through a retrograde pathway is discussed [1].

High impact information on Anterior Thalamic Nuclei

• In the thalamus, PLC-I is localized to neurons in the reticular thalamic nucleus, in the medial subdivision of the mediodorsal thalamic nucleus, and in the anteromedial thalamic nucleus [2].
• They are also transiently coexpressed in principal neurons of the anterodorsal nucleus, but IGF-I mRNA disappears from this structure shortly after birth, while IGFBP5 mRNA remains highly abundant here in the adult [3].
• The laminar distribution of acetylcholine receptors in rat cingulate cortex and their localization to axons of neurons in the anterior thalamic nuclei (ATN) were evaluated with the muscarinic antagonist [3H]propylbenzilylcholine mustard (PrBCM) in vitro [4].
• Oxotremorine produced significant effects in the frontoparietal cortex and anterior thalamic nuclei [5].
• Autoradiographic analysis, using the [14C]-deoxyglucose method, showed increased glucose utilization in the ventral and ventral anterior thalamic nuclei and decreased glucose utilization in the cortex and molecular layer of the hippocampus [6].

Biological context of Anterior Thalamic Nuclei

• In contrast to Wistar, Sprague-Dawley brains contained NPFF1 binding sites in the cortical and spinal cord areas, the accumbens nucleus, the anterodorsal thalamic nucleus, the parafascicular thalamic nucleus, the inferior colliculus and the nucleus of the solitary tract [7].

Anatomical context of Anterior Thalamic Nuclei

• In situ hybridization demonstrated that NB-3 mRNA was preferentially expressed in the accessory olfactory bulb, layers II/III and V of the cerebral cortex, piriform cortex, anterior thalamic nuclei, locus coeruleus of the pons and mesencephalic trigeminal nucleus, and in Purkinje cells of the cerebellum [8].
• Fibers from the basolateral nucleus of the amygdala were found to innervate selectively acetylcholinesterase-poor striosomes demonstrated in the caudate nucleus and butyrylcholinesterase-rich zones observed in the anterodorsal nucleus accumbens [9].
• Unexpectedly, we found robust Narp expression in several discrete areas linked to the vestibular system: the anterodorsal nucleus (ADN) of the thalamus, which relays head orientation information to the cortex, the lateral vestibulospinal (Deiters') nucleus and Purkinje cells in the flocculonodular lobe of the cerebellum [10].
• These investigations found that in utero ethanol exposure significantly decreased norepinephrine reuptake sites in the dorsomedial hypothalamic nucleus and anteroventral thalamic nucleus [11].
• Neuroanatomical effects of chronic ethanol consumption on dorsomedial and anterior thalamic nuclei and on substantia innominata in mice [12].

Associations of Anterior Thalamic Nuclei with chemical compounds

• In vivo monitoring of evoked noradrenaline release in the rat anteroventral thalamic nucleus by continuous amperometry [13].
• A moderate 5-HT innervation was observed in the anterior nuclear group [14].
• At the level of the anterior nuclear group, GABA-positive cells and terminals abounded in the anterodorsal nucleus but were much less numerous in the anteromedial and anteroventral nuclei [15].
• The first study revealed that neurotoxic lesions of the anterior thalamic nuclei and radiofrequency lesions of the fornix both produce equivalent performance deficits [16].
• One day after injection of Fast Blue into the anterior thalamic nuclei or Gudden's tegmental nuclei, Nuclear Yellow was injected into Gudden's tegmental nuclei or the nucleus reticularis tegmenti pontis and the medial pontine nucleus [17].

Gene context of Anterior Thalamic Nuclei

• In situ hybridization indicated that Eif2s3x mRNA was expressed preferentially in specific brain regions including the habenula, anterodorsal thalamic nucleus, hippocampus, hypothalamus, and cerebellum [18].
• SRIF neurons and fibers were found in several hypothalamic and anterior thalamic nuclei as well as all regions of the corpus striatum [19].
• Mint1 mRNA expression was greatest in the limbic system including cingulate cortex, hippocampus, anterior thalamic nuclei, medial habenular nucleus, and mammillary body [20].
• Other major sites of PTH/PTHrP receptor expression included the anterodorsal nucleus of the thalamus, basolateral amygdala, entorhinal cortex, parasubiculum, cells in the Purkinje cell layer of the cerebellum, vestibular nuclei, ventral cochlear nucleus, the motor nucleus of the trigeminal, and the facial and external cuneate nuclei [21].
• Retrograde transport of horseradish peroxidase (HRP) was combined with choline acetyltransferase (ChAT) immunohistochemistry to study cholinergic projections to the anterior thalamic nuclei in the rat [22].

Analytical, diagnostic and therapeutic context of Anterior Thalamic Nuclei

• Therefore, we used whole-cell recording techniques in the in vitro brain slices to examine the effects of serotonin on neurons of the anterodorsal nucleus of the thalamus (ADn) [23].
• We combined retrograde transport of horseradish peroxidase (HRP) with 5-hydroxytryptamine (5-HT) immunohistochemistry to study serotoninergic projections to the anterior thalamic nuclei (ATN) of the rat [24].

References