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Gene Review

SPANXN1  -  SPANX family, member N1

Homo sapiens

Synonyms: CT11.6, Nuclear-associated protein SPAN-Xn1, SPANX family member N1, SPANX-N1, Sperm protein associated with the nucleus on the X chromosome N1
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Disease relevance of SPANXN1

  • Similarly to SPANX-A/D, human SPANX-N genes are expressed in normal testis and some melanoma cell lines; testis-specific expression of SPANX is also conserved in mouse [1].

High impact information on SPANXN1

  • Analysis of these clones and search of the human genome sequence revealed an uncharacterized group of genes, SPANX-N, which are present in all primates as well as in mouse and rat [1].
  • It is concluded that the duplication of the SPANX-N gene family that occurred 6-11 MYA resulted in a new gene family, SPANXA/D, that plays a role during spermiogenesis [2].


  1. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. Kouprina, N., Mullokandov, M., Rogozin, I.B., Collins, N.K., Solomon, G., Otstot, J., Risinger, J.I., Koonin, E.V., Barrett, J.C., Larionov, V. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. Westbrook, V.A., Schoppee, P.D., Vanage, G.R., Klotz, K.L., Diekman, A.B., Flickinger, C.J., Coppola, M.A., Herr, J.C. Mol. Hum. Reprod. (2006) [Pubmed]
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